Aldose reductase and advanced glycation endproducts inhibitory effect of Phyllostachys nigra

被引：51

作者：

Jung, Sang Hoon ^{[1
]}

Lee, Jung Min ^{[1
]}

Lee, Hee Ju ^{[1
]}

Kim, Chul Young ^{[1
]}

Lee, Eun Ha ^{[1
]}

Um, Lyung Hun ^{[1
]}

机构：

[1] Korea Inst Sci & Technol, Nat Prod Res Ctr, Gangneung Inst, Kangnung 210340, South Korea

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2007年 / 30卷 / 08期

关键词：

aldose reductase; advanced glycation endproduct; phyllostachys nigra; luteolin 6-C-(6"-O-trans-caffeoylglucoside); antioxidant; diabetic complications;

D O I：

10.1248/bpb.30.1569

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

To evaluate active principles for diabetic complications from the black bamboo leaves, Phyllostachys nigra, eight compounds were isolated and tested for their effects on rat lens aldose reductase and advanced glycation endproducts. As a result, luteolin 6-C-(6 ''-O-trans-caffeoylglucoside) was found to show a strong aldose reductase and advanced glycation endproducts inhibition. This compound showed antioxidative activity measured in Photochem (R) apparatus. It is concluded, therefore, that luteolin 6-C-(6 ''-O-trans-caffeoylglucoside) (6), a flavone of this plant, have antioxidative as well as aldose reductase and advanced glycation endproducts inhibitory effects. As a result, this compound could be offered as a leading compound for further study as a new natural products drug for diabetic complications.

引用

页码：1569 / 1572

页数：4

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