Emodin: A Review of its Pharmacology, Toxicity and Pharmacokinetics

被引：845

作者：

Dong, Xiaoxv ^{[1
]}

Fu, Jing ^{[1
]}

Yin, Xingbin ^{[1
]}

Cao, Sali ^{[1
]}

Li, Xuechun ^{[1
]}

Lin, Longfei ^{[1
]}

Huyiligeqi ^{[1
,2
]}

Ni, Jian ^{[1
]}

机构：

[1] Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 100102, Peoples R China

[2] Inner Mongolia Univ Nationalities, Affiliated Hosp, Tongliao 028000, Peoples R China

来源：

PHYTOTHERAPY RESEARCH | 2016年 / 30卷 / 08期

关键词：

emodin; pharmacology; toxicology; pharmacokinetics; mechanisms; NF-KAPPA-B; ENDOPLASMIC-RETICULUM STRESS; IN-VITRO; PPAR-GAMMA; POLYGONUM-CUSPIDATUM; DOWN-REGULATION; UDP-GLUCURONOSYLTRANSFERASES; FIBRONECTIN EXPRESSION; INFLAMMATORY RESPONSE; INHIBITING ACTIVATION;

D O I：

10.1002/ptr.5631

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Emodin is a natural anthraquinone derivative that occurs in many widely used Chinese medicinal herbs, such as Rheum palmatum, Polygonum cuspidatum and Polygonum multiflorum. Emodin has been used as a traditional Chinese medicine for over 2000years and is still present in various herbal preparations. Emerging evidence indicates that emodin possesses a wide spectrum of pharmacological properties, including anticancer, hepatoprotective, antiinflammatory, antioxidant and antimicrobial activities. However, emodin could also lead to hepatotoxicity, kidney toxicity and reproductive toxicity, particularly in high doses and with long-term use. Pharmacokinetic studies have demonstrated that emodin has poor oral bioavailability in rats because of its extensive glucuronidation. This review aims to comprehensively summarize the pharmacology, toxicity and pharmacokinetics of emodin reported to date with an emphasis on its biological properties and mechanisms of action. Copyright (c) 2016 John Wiley & Sons, Ltd.

引用

页码：1207 / 1218

页数：12

共 121 条

[1]

Peroxisome proliferator-activated receptor γ agonist provides superior renal protection versus angiotensin-converting enzyme inhibition in a rat model of type 2 diabetes with obesity [J].