The free radical theory of aging

被引：382

作者：

Harman, D ^{[1
]}

机构：

[1] Univ Nebraska, Coll Med, Dept Med, Omaha, NE 68198 USA

来源：

ANTIOXIDANTS & REDOX SIGNALING | 2003年 / 5卷 / 05期

关键词：

D O I：

10.1089/152308603770310202

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aging is the accumulation of changes that increase the risk of death. Aging changes can be attributed to development, genetic defects, the environment, disease, and an inborn process: the aging process. The latter is the major risk factor for disease and death after age 28 in the developed countries. In these countries, average life expectancies at birth (ALE-B) now range from 76 to 79 years, 6-9 years less than the limit of similar to85 years imposed by aging. Aging changes may be caused by free radical reactions. The extensive studies based on this possibility hold promise that the ALE-B can be extended to >85 years and the maximum life span increased.

引用

页码：557 / 561

页数：5

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