Molecular approaches to spinal cord repair

被引：154

作者：

David, S ^{[1
]}

Lacroix, S ^{[1
]}

机构：

[1] McGill Univ, Ctr Hlth, Montreal Gen Hosp, Inst Res,Ctr Res Neurosci, Montreal, PQ H3G 1A4, Canada

来源：

ANNUAL REVIEW OF NEUROSCIENCE | 2003年 / 26卷

关键词：

Nogo-A; myelin-associated glycoprotein; oligodendrocyte-myelin glycoprotein; chondroitin sulfate proteoglycan; axon regeneration;

D O I：

10.1146/annurev.neuro.26.043002.094946

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Axon growth inhibitors associated with myelin and the glial scar contribute to the failure of axon regeneration in the injured adult mammalian central nervous system (CNS). A number of these inhibitors, their receptors, and signaling pathways have been identified. These inhibitors can now be neutralized by a variety of approaches that point to the possibility of developing new therapeutic strategies to stimulate regeneration after spinal cord injury.

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收藏

页码：411 / 440

页数：30

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