Stereoselective synthesis of 6-methyl-9-(2-deoxy-beta-D-erythro-pentofuranosyl)purine

被引：8

作者：

AndersonMcKay, JE

Both, GW

Simpson, GW

机构：

[1] CSIRO,DIV CHEM & POLYMERS,CLAYTON,VIC 3169,AUSTRALIA

[2] CSIRO,DIV BIOMOLEC ENGN,SYDNEY LAB,N RYDE,NSW 2113,AUSTRALIA

来源：

NUCLEOSIDES & NUCLEOTIDES | 1996年 / 15卷 / 7-8期

关键词：

D O I：

10.1080/07328319608002431

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The coupling of the sodium salt of 6-methylpurine with 2-deoxy-3,5-di-O-p-toluoyl-alpha-D-erythro-pentofuranosyl chloride in acetonitrile gives the di-O-p-toluoyl protected 9-beta nucleoside regio- and stereo-selectively in good yield. Methoxide deprotection followed by preparative hplc then affords pure 6-methyl-9-(2-deoxy-beta-D- erythro-pentofuranosyl)purine.

引用

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页码：1307 / 1313

页数：7

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