Comparison of agonistic flare-up-protocol and antagonistic multiple dose protocol in ovarian stimulation of poor responders: results of a prospective randomized trial

被引：133

作者：

Akman, MA ^{[1
]}

Erden, HF ^{[1
]}

Tosun, SB ^{[1
]}

Bayazit, N ^{[1
]}

Aksoy, E ^{[1
]}

Bahceci, M ^{[1
]}

机构：

[1] German Hosp, IVF Unit, Istanbul, Turkey

来源：

HUMAN REPRODUCTION | 2001年 / 16卷 / 05期

关键词：

cetrorelix; GnRH antagonist; IVF-embryo transfer; microdose GnRH agonist flare-up; poor responders;

D O I：

10.1093/humrep/16.5.868

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The management of poor responders in IVF has always been a big problem, The ideal approach has yet to be formulated. In this study we aim to compare two alternative stimulation protocols. A total of 48 poor responder patients described from previous cycles were included and grouped into two: group I consisted of 24 patients in 24 cycles in which leuprolide acetate (40 mug s.c. per day) was initiated on cycle day 2 followed by exogenous gonadotrophins on cycle day 3; group II consisted of 24 patients in 24 cycles in which ovarian stimulation included gonadotrophin-releasing hormone (GnRH) antagonist (cetrorelix, 0.25 mg daily during late follicular phase) administration While only the oestradiol concentrations on the day of HCG were lower in group II compared with group I, the clinical pregnancy and implantation rates among groups did not show any significance, The impact of these two regimens in ovarian stimulation of poor responders seem to be same and to establish these results further randomized studies with larger sample sizes are required.

引用

页码：868 / 870

页数：3

共 13 条

[1] Will GnRH antagonists provide new hope for patients considered 'difficult responders' to GnRH agonist protocols? [J].