Analysis of the effect of aging on the response to hypoxia by cDNA microarray

被引：28

作者：

Kim, H

Lee, DK

Choi, JW

Kim, JS

Park, SC

Youn, HD

机构：

[1] Seoul Natl Univ, Coll Med, Dept Biochem & Mol Biol, Inst Canc Res, Seoul 110799, South Korea

[2] Toolgen Inc, Taejon 305390, South Korea

[3] Seoul Natl Univ, Coll Med, Aging & Apoptosis Res Ctr, Seoul 110510, South Korea

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2003年 / 124卷 / 8-9期

关键词：

aging; hypoxia; cDNA microarray; hypoxia-inducible factor; angiogenesis;

D O I：

10.1016/S0047-6374(03)00166-0

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Little is known about the detail of hypoxia-responsive gene expression patterns in advanced age, even though aging is thought to be partially associated with a decreased response to hypoxia. In the present study, we identified several hypoxia-inducible genes and investigated the effect of aging on hypoxic gene expression profiles using cDNA microarray analysis of young/old human diploid fibroblasts. Of 7458 genes in the microarray, we found that genes involved in angiogenesis, defense against oxidative stress, and transcription regulation are severely impaired in senescent cell, which is consistent with the fact that aged cells have attenuated responses to various stimuli. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：941 / 949

页数：9

共 38 条

[1] Stabilization of wild-type p53 by hypoxia-inducible factor 1α [J].