A polymorphism (5-HTTLPR) in the serotonin transporter promoter gene is associated with DSM-IV depression subtypes in seasonal affective disorder

被引:85
作者
Willeit, M
Praschak-Rieder, N
Neumeister, A
Zill, P
Leisch, F
Stastny, J
Hilger, E
Thierry, N
Konstantinidis, A
Winkler, D
Fuchs, K
Sieghart, W
Aschauer, H
Ackenheil, M
Bondy, B
Kasper, S
机构
[1] Ctr Addict & Mental Hlth, Toronto, ON M5T 1R8, Canada
[2] Univ Hosp Psychiat, Dept Gen Psychiat, Vienna, Austria
[3] NIMH, Inst Hlth, Mood & Anxiety Disorders Res Program, Bethesda, MD 20892 USA
[4] Univ Munich, Univ Hosp Psychiat, Dept Neurochem, Munich, Germany
[5] Univ Technol, Dept Stat & Probabil Theory, Vienna, Austria
[6] Brain Res Inst, Div Biochem & Mol Biol, Vienna, Austria
关键词
melancholic; atypical; mood disorders; nosology; genetics;
D O I
10.1038/sj.mp.4001392
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Serotonergic mechanisms are thought to play an important role in the pathogenesis of seasonal affective disorder (SAD). The expression of the serotonin transporter (5-HTT) is regulated in part by an insertion/deletion polymorphism in the serotonin transporter gene promoter region (5-HTTLPR). The 5-HTTLPR short allele (s) has been associated with anxiety-related personality traits and depression, and one study observed an association between the 5-HTTLPR s-allele and SAD and the trait of seasonality. We genotyped 138 SAD patients and 146 healthy volunteers with low seasonality for 5-HTTLPR. No difference between patients and controls was found for genotype distribution and s-allele frequency. However, genotype distribution and allele frequencies were strongly associated with DSM-IV depression subtypes. Melancholic depression was associated with the 5-HTTLPR long (l) allele and atypical depression with the 5-HTTLPR s-allele (two-sided Fisher's exact test: genotype distribution: P=0.0038; allele frequencies: P=0.007). Our data are compatible with the hypothesis of a disease process that is not causally related to 5-HTTLPR, but involves 5-HT neurotransmission and 5-HTTLPR somewhere on its way to phenotypic disease expression.
引用
收藏
页码:942 / 946
页数:5
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