Identification of a new member of transforming growth factor-beta superfamily in Drosophila:: The first invertebrate activin gene

被引：35

作者：

Kutty, G ^{[1
]}

Kutty, RK ^{[1
]}

Samuel, W ^{[1
]}

Duncan, T ^{[1
]}

Jaworski, C ^{[1
]}

Wiggert, B ^{[1
]}

机构：

[1] NEI, Retinal Cell & Mol Biol Lab, NIH, Bethesda, MD 20892 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1998年 / 246卷 / 03期

关键词：

D O I：

10.1006/bbrc.1998.8678

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Activins, a subgroup of the transforming growth factor-beta (TGP-beta) superfamily, have been extensively studied in vertebrates for their roles in growth and development. However, activins are not thought to be expressed in invertebrates. The identification of the first invertebrate activin gene is reported here. A genomic clone representing 102 F region of the Drosophila chromosome 4 is found to encode a putative activin beta. The predicted protein sequence has a multibasic protease site that would generate a mature C-terminal peptide containing 113 amino acids showing >60% similarity to the vertebrate activin beta(B) (inhibin beta(B)) sequences. A TGF-beta family signature as well as all 9 cysteine residues conserved in the vertebrate activins are also present in this mature peptide sequence. Northern blot and RT-PCR analyses indicated that the activin beta gene is expressed in embryo, larva and adult stages of Drosophila. (C) 1998 Academic Press.

引用

页码：644 / 649

页数：6

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