Lipase-catalyzed irreversible transesterification of secondary alcohols using isopropenyl acetate

被引：10

作者：

Ghanem, A ^{[1
]}

Schurig, V

机构：

[1] Univ Geneva, Dept Organ Chem, CH-1211 Geneva 4, Switzerland

[2] Univ Tubingen, Inst Organ Chem, D-75076 Tubingen, Germany

来源：

MONATSHEFTE FUR CHEMIE | 2003年 / 134卷 / 08期

关键词：

enantiomeric resolution; irreversible transesterification; lipase; secondary alcohols; gas chromatography;

D O I：

10.1007/s00706-003-0025-1

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Asymmetric acetylation of a set of secondary alcohols with the innocuous acyl donor isopropenyl acetate catalyzed by a lipase from Pseudomonas cepacia immobilized on ceramic particles (PSL-C) in toluene as organic medium afforded the chiral alcohols and the corresponding acetates in high enantiomeric excess (up to 99%). An effective baseline separation of the enantiomers of both substrate and product was performed in one analysis without derivatization using gas chromatography on a new chiral stationary phase (CSP) Chirasil-beta-Dex containing an undecamethylene spacer (C11-Chirasil-Dex).

引用

页码：1151 / 1157

页数：7

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