Postsynaptic silent synapses: evidence and mechanisms

被引：87

作者：

Isaac, JTR ^{[1
]}

机构：

[1] Univ Bristol, Dept Anat, MRC, Ctr Synapt Plast, Bristol BS8 1TD, Avon, England

来源：

NEUROPHARMACOLOGY | 2003年 / 45卷 / 04期

关键词：

LTP; LTD; AMPA receptors; NMDA receptors; synaptic plasticity;

D O I：

10.1016/S0028-3908(03)00229-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In this review I discuss the evidence that some glutamatergic synapses exist that lack surface-expressed postsynaptic AMPA receptors (AMPARs) but contain NMDA receptors opposed to a functional release site. I have summarised the electrophysiological, anatomical and cell biological evidence for such postsynaptically silent synapses, and data that support the idea of rapid AMPAR insertion at silent synapses during long-term potentiation (LTP). I also discuss recent findings suggesting that developmental and activity-dependent alteration in the postsynaptic glutamate receptor composition is a general principle that occurs for other receptor subtypes. This review is not intended to provide a full discussion of possible presynaptic mechanisms for silent synapses; these are covered in the accompanying recent article [Voronin and Cherubini (this issue)]. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：450 / 460

页数：11

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