A large-scale low-cost access to the lithium 2,2,6,6-tetramethylpiperidide precursor

被引：20

作者：

Kampmann, D

Stuhlmüller, G

Simon, R

Cottet, F

Leroux, F

Schlosser, M ^{[1
]}

机构：

[1] Clariant Acetyl Bldg Blocks, D-86368 Gersthofen, Germany

[2] Ecole Polytech Fed, Inst Chem Sci & Engn, CH-1015 Lausanne, Switzerland

来源：

SYNTHESIS-STUTTGART | 2005年 / 06期

关键词：

continuous reaction; hydrazone dediazotation; lithium 2,2,6,6-tetramethylpiperidide; 2,2,6,6-tetramethylpiperidine; Wolff-Kishner reduction;

D O I：

10.1055/s-2004-834856

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Wolff-Kishner-Huang reduction of the cheap 2,2,6,6-tetramethyl-4-piperidinone (2) provides the expensive 2,2,6,6-tetramethy1piperidine (1), the precursor to lithium 2,2,6,6-tetramethylpiperidide, in high yield. As specified in the detailed protocol, the reaction can be conveniently carried out on a > 10 mol laboratory scale.

引用

页码：1028 / 1029

页数：2

共 17 条

[1]

Anelli P. L., 1990, ORG SYNTH, V69, P212

[2]

ANELLI PL, 1987, J ORG CHEM, V52, P2559

[3] PREPARATION OF ISOBENZOFURAN ARYNE CYCLOADDUCTS [J].