A synthetic divalent cholera toxin glycocalix[4]arene ligand having higher affinity than natural GM1 oligosaccharide

被引：71

作者：

Arosio, D

Fontanella, M

Baldini, L

Mauri, L

Bernardi, A

Casnati, A

Sansone, F

Ungaro, R

机构：

[1] Univ Milan, Dipartimento Chim Organ & Ind, I-20133 Milan, Italy

[2] CISI, Ctr Eccellenza, I-20133 Milan, Italy

[3] Univ Parma, Dipartimento Chim Organ & Ind, I-43100 Parma, Italy

[4] Univ Milan, Dipartimento Chim Biochim & Biotecnol Med, Segrate, MI, Italy

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 11期

关键词：

D O I：

10.1021/ja0444029

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A high-affinity ligand of cholera toxin, the divalent glycocalix[4]arene 1, was obtained by exploiting a combination of structure-based design of glycomimetic monovalent ligands and affinity enhancements by multivalent presentation through a calix[4]arene scaffold. It exhibits a slightly higher affinity for the toxin than its natural ligand, the GM1 oligosaccharide. Copyright © 2005 American Chemical Society.

引用

页码：3660 / 3661

页数：2

共 32 条

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