Tumor necrosis factor family members and inflammatory bowel disease

被引：61

作者：

Wang, J ^{[1
]}

Fu, YX ^{[1
]}

机构：

[1] Univ Chicago, Dept Pathol, Chicago, IL 60637 USA

来源：

IMMUNOLOGICAL REVIEWS | 2005年 / 204卷

关键词：

D O I：

10.1111/j.0105-2896.2005.00218.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Tumor necrosis factor (TNF) is one of the most potent effector cytokines in the pathogenesis of inflammatory bowel disease (IBD). Previous studies strongly implicate the critical involvement of several TNF family members in human IBD. This review focuses on the recent studies of TNF family members in IBD development. In particular, we discuss the findings about LIGHT (homologous to lymphotoxins, inducible expression, competes with herpes simplex virus glycoprotein D for herpes viral entry mediator, a receptor expressed on T lymphocytes) in the pathogenesis of IBD, and the potential mechanisms by which LIGHT induces IBD. Such mechanisms may also apply to other TNF family members.

引用

页码：144 / 155

页数：12

共 91 条

[1]

BERGER J, 1968, J UROL NEPHROL, V74, P694

[2] ALPHA-4 INTEGRINS MEDIATE LYMPHOCYTE ATTACHMENT AND ROLLING UNDER PHYSIOLOGICAL FLOW [J].