Structural brain changes in Parkinson disease with dementia

被引:213
作者
Summerfield, C
Junqué, C
Tolosa, E
Salgado-Pineda, P
Gómez-Ansón, B
Martí, MJ
Pastor, P
Ramírez-Ruíz, B
Mercader, J
机构
[1] Univ Barcelona, Inst Invest Biomed August Pi & Sunyer, Dept Psiquiat & Psicobiol, E-08036 Barcelona, Spain
[2] Hosp Clin Barcelona, Inst Clin Malalties Sistema Nervios, Neurol Serv, Parkinsons Dis & Movement Disorders Unit, Barcelona, Spain
[3] Hosp Clin Barcelona, Ctr Diagnost Imatge, Barcelona, Spain
关键词
D O I
10.1001/archneur.62.2.281
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: Parkinson disease with dementia (PDD) results from neuropathological changes in cortical and subcortical brain regions. Voxel-based morphometric analysis of magnetic resonance images can contribute to in vivo identification of the cerebral regions predominantly involved in PDD. Objective: To identify structural cerebral regions most closely related to the presence of PDD. Design: Magnetic resonance images were obtained from 16 patients who had PDD, 13 patients with PD without dementia, and 13 age-matched healthy control subjects. Gray matter volumes were compared using optimized voxel-based morphometric analyses. Results: Compared with healthy controls, patients with PDD showed gray matter volume decreases in several of the following regions: bilateral putamen, accumbens nuclei, left side of the thalamus, bilateral hippocampus, parahippocampal region, and anterior cingulate gyrus. Patients with PD also showed gray matter reductions compared with healthy controls in the right side of the hippocampus, left anterior cingulate gyrus, and left superior temporal gyrus. Conclusions: The hippocampus, thalamus, and anterior cingulate are the regions most affected in PDD. Our results agree with recent neuropathological findings suggesting the involvement of the limbic and cortical areas in PD.
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页码:281 / 285
页数:5
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