First-trimester ultrasound examination and the outcome of monochorionic twin pregnancies

Objective To refine the incidence of abnormal first-trimester ultrasound measurements and their correlation with the outcome of monochorionic diamniotic pregnancies. Methods First-trimester crown-rump length (CRL) and nuchal translucency thickness (NT) measurements were studied in three subgroups of a total of 200 monochorionic twin gestations referred to our center between June 2002 and February 2006. Intertwin CRL discordance was defined as >10% and the 95th percentile of NT thickness for gestational age was used. The first group of 103 consecutive unselected monochorionic diamniotic twin pregnancies was prospectively followed up from 11-14 weeks onwards, throughout the pregnancy. The second group of 136 nonconsecutive monochorionic diamniotic twin pregnancies including 64 that developed TTTS was studied retrospectively. The third group of 100 consecutive cases of TTTS studied retrospectively for the correlation between first trimester measurements and staging and timing of occurrence of TTTS. Results In group 1, the incidence of TTTS was 5 in 103 (5%, 95CI [0.7-91). Large intertwin CRL discordance and increased NT were correlated with perinatal death. In group 2, no significant association was found between first-trimester parameters and the development of TTTS but discordance in early second trimester biometry and Doppler were. In group three, a positive correlation was found between the intertwin discordance in CRL and early occurrence of TTTS before 20 weeks of gestation (p = 0.02). Conclusion Monochorionic twin gestations who ultimately develop TTTS may exhibit intertwin difference in growth as early as 11-14 weeks of gestation. The earlier the discordance the earlier the development of the disease. Copyright (C) 2007 John Wiley & Sons, Ltd.