Adiponectin receptor binding proteins - recent advances in elucidating adiponectin signalling pathways

被引：72

作者：

Buechler, Christa ^{[1
]}

Wanninger, Josef ^{[1
]}

Neumeier, Markus ^{[1
]}

机构：

[1] Univ Hosp Regensburg, Dept Internal Med 1, D-93042 Regensburg, Germany

来源：

FEBS LETTERS | 2010年 / 584卷 / 20期

关键词：

Adiponectin receptor; APPL; Endocytosis; ACTIVATED C-KINASE; MOLECULAR-WEIGHT ADIPONECTIN; HUMAN CEREBROSPINAL-FLUID; PRIMARY HUMAN HEPATOCYTES; FATTY LIVER-DISEASE; INSULIN-RESISTANCE; ADIPOSE-TISSUE; APOLIPOPROTEIN-B; MUSCLE-CELLS; T-CADHERIN;

D O I：

10.1016/j.febslet.2010.09.035

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Adiponectin whose systemic levels are reduced in obesity-related diseases ameliorates insulin sensitivity and regulates biological processes like apoptosis, proliferation, migration and inflammation. Adiponectin binds to adiponectin receptors, AdipoR1 and AdipoR2, which are ubiquitously expressed. Clathrin-dependent endocytosis of AdipoR1 and adiponectin has been demonstrated to modulate adiponectin bioactivity. Recently, APPL1 has been identified as an AdipoR1 and AdipoR2 binding protein. Furthermore, activated protein kinase C1, endoplasmic reticulum protein 46 and protein kinase CK2 beta subunit form a complex with AdipoR1. This review summarizes recent studies exploiting heterologous expression of adiponectin receptors in yeast, and the type and function of the recently described adiponectin receptor associated proteins. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：4280 / 4286

页数：7

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