Bisphosphonates' antitumor activity: An unravelled side of a multifaceted drug class

被引：132

作者：

Clezardin, Philippe ^{[1
]}

机构：

[1] Univ Lyon 1, INSERM, Fac Med Lyon Est Domaine Laennec, Res Unit U664, F-69372 Lyon, France

来源：

BONE | 2011年 / 48卷 / 01期

关键词：

Bisphosphonate; Metastasis; Breast; Gamma delta T; Angiogenesis; DELTA-T-CELLS; PLUS ZOLEDRONIC ACID; ATP ANALOG FORMATION; TUMOR-GROWTH; BONE METASTASIS; CANCER CELLS; IN-VIVO; INHIBITION; PROSTATE; PYROPHOSPHATE;

D O I：

10.1016/j.bone.2010.07.016

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Bisphosphonates, especially nitrogen-containing bisphosphonates (N-Bps), are widely used to preserve and improve bone health in patients with cancer because they inhibit osteoclast-mediated bone resorption. In addition to their effects on bone, preclinical evidence strongly suggests that N-BPs exert anticancer activity without the involvement of osteoclasts by interacting with macrophages, endothelial cells and tumor cells, and by stimulating the cytotoxicity of gamma delta T cells, a subset of human T cells. This review examines the current insights and fronts of ongoing preclinical research on N-BPs' antitumor activity. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：71 / 79

页数：9

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