Supramolecular interaction of ethylenediamine linked β-cyclodextrin dimer and berberine hydrochloride by spectrofluorimetry and its analytical application

被引：26

作者：

Liu, Fang ^{[1
]}

Liang, Hui-ling ^{[1
]}

Xu, Ke-hua ^{[1
]}

Tong, Li-li ^{[1
]}

Tang, Bo ^{[1
]}

机构：

[1] Shandong Normal Univ, Coll Chem, Engn Res Ctr Pesticide & Med Intermediate Clean, Minist Educ, Jinan 250014, Peoples R China

来源：

TALANTA | 2007年 / 74卷 / 01期

基金：

中国国家自然科学基金;

关键词：

ethylenediamine linked beta-CD dimer; berberine hydrochloride; supramolecular interaction; spectrofluorimetry;

D O I：

10.1016/j.talanta.2007.05.048

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The supramolecular interaction of P-cyclodextrin dimer with berberine hydrochloride was studied in aqueous KH2PO4-H3PO4 buffer solution of pH 2.00 at room temperature by spectrofluorimetry. The apparent association constant of the complex was 1.53 x 10(4) L mol(-1). Based on the significant enhancement of fluorescence intensity of supramolecular sandwich complexes, a spectrofluori metric method with high sensitivity and selectivity was developed for the determination of berberine hydrochloride in aqueous solution in presence of ethylenediamine linked P-CD dimer. The linear range of the method was 12.8-1.00 x 10(4) ng mL(-1) with the detection limit 3.6 ng mL(-1). There was no interference from the normally used in tablets and serum constituents. The proposed method was successfully applied to the determination of berberine hydrochloride in tablets and serum. And then it has a promising potential in therapeutic drug monitoring, pharmokinetis and clinical application. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：140 / 145

页数：6

共 32 条

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