Caspase 7 is a Positional candidate gene for IDDM 17 in a Bedouin Arab family

被引：17

作者：

Babu, SR ^{[1
]}

Bao, F ^{[1
]}

Roberts, CM ^{[1
]}

Martin, AK ^{[1
]}

Gowan, K ^{[1
]}

Eisenbarth, GS ^{[1
]}

Fain, PR ^{[1
]}

机构：

[1] Univ Colorado, Hlth Sci Ctr, Barbara Davis Ctr Childhood Diabet, Denver, CO 80262 USA

来源：

IMMUNOLOGY OF DIABETES II: PATHOGENESIS FROM MOUSE TO MAN | 2003年 / 1005卷

关键词：

caspase 7 (CASP7); IDDM; 17; Bedouin; locus; gene; chromosome;

D O I：

10.1196/annals.1288.054

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The IDDM 17 locus was mapped to an 8-cM interval at chromosome 10q25.1 based on linkage in a large Bedouin Arab family with 19 affected relatives. Caspase 7 (CASP7), an apoptosis-related cysteine protease, is one of the few known genes in this region. CASP7 is involved in the activation cascade of caspases responsible for apoptosis execution. Only 1 of the 18 SNPs in CASP7 (SNP144692) differed significantly in frequency in the haplotypes found in affected individuals compared to control Bedouin haplotypes. This same SNP showed evidence of association with diabetes in a subset of patients (DR3/DR4*0302) from HBDI families.

引用

页码：340 / 343

页数：4

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