Cognitive Training Enhances Intrinsic Brain Connectivity in Childhood

被引:99
作者
Astle, Duncan E. [1 ]
Barnes, Jessica J. [1 ]
Baker, Kate [2 ]
Colclough, Giles L. [3 ]
Woolrich, Mark W. [3 ]
机构
[1] MRC, Cognit & Brain Sci Unit, Cambridge CB2 7EF, England
[2] Univ Cambridge, Dept Med Genet, Cambridge CB2 7EF, England
[3] Univ Oxford, Oxford Ctr Human Brain Act, Oxford OX3 7JX, England
基金
英国惠康基金; 英国医学研究理事会;
关键词
Cognitive training; development; electrophysiology; magnetoencephalography; working memory; WORKING-MEMORY; ATTENTION; MEG; CHILDREN; MODULATION; ALPHA;
D O I
10.1523/JNEUROSCI.4517-14.2015
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In human participants, the intensive practice of particular cognitive activities can induce sustained improvements in cognitive performance, which in some cases transfer to benefits on untrained activities. Despite the growing body of research examining the behavioral effects of cognitive training in children, no studies have explored directly the neural basis of these training effects in a systematic, controlled fashion. Therefore, the impact of training on brain neurophysiology in childhood, and the mechanisms by which benefits may be achieved, are unknown. Here, we apply new methods to examine dynamic neurophysiological connectivity in the context of a randomized trial of adaptive working memory training undertaken in children. After training, connectivity between frontoparietal networks and both lateral occipital complex and inferior temporal cortex was altered. Furthermore, improvements in working memory after training were associated with increased strength of neural connectivity at rest, with the magnitude of these specific neurophysiological changes being mirrored by individual gains in untrained working memory performance.
引用
收藏
页码:6277 / 6283
页数:7
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