Surfaces That Sequester Serum-Borne Heparin Amplify Growth Factor Activity

被引：51

作者：

Hudalla, Gregory A. ^{[1
]}

Koepsel, Justin T. ^{[1
]}

Murphy, William L. ^{[1
,2
]}

机构：

[1] Univ Wisconsin Madison, Dept Biomed Engn, Wisconsin Inst Med Res 5009, Madison, WI 53705 USA

[2] Univ Wisconsin Madison, Dept Pharmacol, Dept Biomed Orthoped & Rehabil, Wisconsin Inst Med Res 5009, Madison, WI 53705 USA

来源：

ADVANCED MATERIALS | 2011年 / 23卷 / 45期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

monolayers; biomedical applications; surface modification; BINDING DOMAIN; CELL ADHESION; FIBRONECTIN; ORGANIZATION; ADSORPTION; MONOLAYERS; SUBSTRATE; PROTEINS; PEPTIDE; CULTURE;

D O I：

10.1002/adma.201103046

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Surfaces presenting a heparin-binding peptide can non-covalently sequester heparin from culture supplements, such as fetal bovine serum. In turn, sequestered, serum-borne heparin can non-covalently localize growth factors at the cell-material interface, resulting in amplified growth factor bioactivity.

引用

页码：5415 / +

页数：5

共 21 条

[1]

Organization, structure and activity of proteins in monolayers [J].