MD-2 binds to bacterial lipopolysaccharide

被引：26

作者：

Viriyakosol, S

Kirkland, TN

Soldau, K

Tobias, PS

机构：

[1] Univ Calif San Diego, Dept Pathol & Med, Dept Vet Affairs Med Ctr, San Diego, CA 92161 USA

[2] Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA

来源：

JOURNAL OF ENDOTOXIN RESEARCH | 2000年 / 6卷 / 06期

关键词：

D O I：

10.1177/09680519000060060201

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Many LPS binding proteins have been described, but the exact nature of the LPS receptors that signal cells remains unclear. MD-2 is a molecule that is found in association with Toll-like receptor 4, which has been shown to be a receptor for LPS. We have produced human MD-2 in baculovirus and tested it for LPS binding. MD-2 binds the lipid A region of LPS without the need for LPS binding protein. These data suggest that MD-2 may be binding LPS as part of the TLR4 receptor complex.

引用

收藏

页码：489 / 491

页数：3

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