CD40 and its crucial role as a member of the TNFR family

被引：76

作者：

Vogel, LA ^{[1
]}

Noelle, RJ ^{[1
]}

机构：

[1] Dartmouth Med Sch, Dept Microbiol, Lebanon, NH 03756 USA

来源：

SEMINARS IN IMMUNOLOGY | 1998年 / 10卷 / 06期

关键词：

CD40; tumor necrosis factor receptor; immune system;

D O I：

10.1006/smim.1998.0145

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The cell surface molecule CD40 is a member of the tumor necrosis factor receptor (TNFR) family and plays a pivotal role in the immune system due in part to its wide tissue distribution. Early studies focused on CD40 in B cell biology, but recent work demonstrates a broader role for CD40 in the immune system contributing to cell-mediated as well as humoral immune responses. Disruption of CD40 and its ligand, CD154 leads to immunodeficiency as in the case of hyper IgM syndrome. Likewise, blockade of CD40-CD154 interactions can be exploited to control misguided autoimmune responses. This article provides a brief overview of CD40 with a focus on its involvement in disease and its usefulness as a therapeutic target.

引用

页码：435 / 442

页数：8

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