Inflammatory bowel disease: Are there gender differences in the genetics of signal transduction? A preliminary study of cytosolic low molecular weight protein tyrosine phosphatase

被引:11
作者
Bottini, N
Gloria-Bottini, F
Lucarini, N
Ronchetti, PG
Fontana, L
机构
[1] Univ Roma Tor Vergata, Sch Med, Div Allergol & Clin Immunol, Rome, Italy
[2] Univ Roma Tor Vergata, Sch Med, Div Prevent & Social Pediat, Rome, Italy
[3] Univ Camerino, Sch Sci, Dept MCA Biol, I-62032 Camerino, Italy
[4] San Camillo Hosp, Div Gastroenterol, Rome, Italy
关键词
D O I
10.1155/2000/101739
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The phenotype of cytosolic Low Molecular Weight Protein Tyrosine Phosphatase (cLMWPTP or ACP1), an enzyme involved in signal transduction of insulin, PDGF and T-cell receptors, has been determined in 71 patients with Crohn's Disease (CD:37 males and 34 females), 49 patients with Ulcerative Colitis (UC: 27 males and 22 females) and 358 consecutive newborns (194 males and 164 females). cLMWPTP phenotypes showing a high concentration of F isoforms are associated with CD in females and with UC in males. Since PTPases counteract the effects of protein tyrosines kinases, a high concentration of F isoform of cLMWPTP may influence the mucosal response to pathogenic factors, increasing susceptibility to CD in females and to UC in males.
引用
收藏
页码:163 / 166
页数:4
相关论文
共 22 条
[1]  
AKOLKAR PN, 1977, AM J GASTROENTEROL, V92, P2241
[2]   EXPRESSION OF GROWTH-FACTOR RECEPTOR-ENCODED MESSENGER-RNA BY COLONIC EPITHELIAL-CELLS IS ALTERED IN INFLAMMATORY BOWEL-DISEASE [J].
ALEXANDER, RJ ;
PANJA, A ;
KAPLANLISS, E ;
MAYER, L ;
RAICHT, RF .
DIGESTIVE DISEASES AND SCIENCES, 1995, 40 (03) :485-494
[3]  
[Anonymous], 1976, Handbook of enzyme electrophoresis in human genetics
[4]   Altered frequency of a promoter polymorphic allele of the kinin B1 receptor gene in inflammatory bowel disease [J].
Bachvarov, DR ;
Landry, M ;
Houle, S ;
Paré, P ;
Marceau, F .
GASTROENTEROLOGY, 1998, 115 (05) :1045-1048
[5]   Familial occurrence and inheritance studies in inflammatory bowel disease [J].
Binder, V ;
Orholm, M .
NETHERLANDS JOURNAL OF MEDICINE, 1996, 48 (02) :53-56
[6]   ACP1 AND HUMAN ADAPTABILITY .1. ASSOCIATION WITH COMMON DISEASES - A CASE-CONTROL STUDY [J].
BOTTINI, E ;
GLORIABOTTINI, F ;
BORGIANI, P .
HUMAN GENETICS, 1995, 96 (06) :629-637
[7]   American families with Crohn's disease have strong evidence for linkage to chromosome 16 but not chromosome 12 [J].
Brant, SR ;
Fu, YF ;
Fields, CT ;
Baltazar, R ;
Ravenhill, G ;
Pickles, MR ;
Rohal, PM ;
Mann, J ;
Kirschner, BS ;
Jabs, EW ;
Bayless, TM ;
Hanauer, SB ;
Cho, JH .
GASTROENTEROLOGY, 1998, 115 (05) :1056-1061
[8]   The Src and signal transducers and activators of transcription pathways as specific targets for low molecular weight phosphotyrosine-protein phosphatase in platelet-derived growth factor signaling [J].
Chiarugi, P ;
Cirri, P ;
Marra, F ;
Raugei, G ;
Fiaschi, T ;
Camici, G ;
Manao, G ;
Romanelli, RG ;
Ramponi, G .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (12) :6776-6785
[9]   Genetic analysis of inflammatory bowel disease in a large European cohort supports linkage to chromosomes 12 and 16 [J].
Curran, ME ;
Lau, KF ;
Hampe, J ;
Schreiber, S ;
Bridger, S ;
Macpherson, AJS ;
Cardon, LR ;
Sakul, H ;
Harris, TJR ;
Stokkers, P ;
Van Deventer, SJH ;
Mirza, M ;
Raedler, A ;
Kruis, W ;
Meckler, U ;
Theuer, D ;
Herrmann, T ;
Gionchetti, P ;
Lee, J ;
Mathew, C ;
Lennard-Jones, J .
GASTROENTEROLOGY, 1998, 115 (05) :1066-1071
[10]   Increased expression of keratinocyte growth factor messenger RNA associated with inflammatory bowel disease [J].
Finch, PW ;
Pricolo, V ;
Wu, A ;
Finkelstein, SD .
GASTROENTEROLOGY, 1996, 110 (02) :441-451