Administration of perilla oil coated with Calshell increases glucagon-like peptide secretion

被引：7

作者：

Adachi, Tetsuya ^{[1
]}

Yanaka, Hiroyuki ^{[2
]}

Kanai, Hitoshi ^{[2
]}

Nozaki, Mayu ^{[2
]}

Takahara, Yoshiyuki ^{[3
]}

Tsuda, Mariko ^{[4
]}

Jonouchi, Tatsuya ^{[1
]}

Tsuda, Kinsuke ^{[4
]}

Hirasawa, Akira ^{[1
]}

Tsujimoto, Gozoh ^{[1
]}

机构：

[1] Kyoto Univ, Dept Genom Drug Discovery Sci, Grad Sch Pharmaceut Sci, Sakyo Ku, Kyoto 6068501, Japan

[2] Kyoto Univ, Lab Metab, Grad Sch Human & Environm Sci, Sakyo Ku, Kyoto 6068501, Japan

[3] KITII Co Ltd, Saiwai Ku, Kawasaki, Kanagawa 2120054, Japan

[4] Pharma Frontier Co Ltd, Nakagyo Ku, Kyoto 6040804, Japan

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2008年 / 31卷 / 05期

关键词：

Calshell; perilla oil; glucagon-like peptide-1; insulin; moose;

D O I：

10.1248/bpb.31.1021

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

Recently, we found that unsaturated long-chain fatty acids (such as a-linolenic acid) promote the secretion of glucagon-like peptide-1 (GLP-1) via G protein-coupled receptor GPR120, which is expressed predominantly in the colon. In order to ensure that the triglycerides or free fatty acids, such as a-linolenic acid, reach the distal intestinal tract effectively, we developed a Calshell technique. Following single treatment of Calshell perilla oil powder, the GLP-1 secretion level was significantly higher than following vehicle treatment, 120 min after treatment. Next, we examined the effects of long-term Calshell perilla oil powder treatment on GLP-1 secretion. Plasma GLP-1 level of Calshell perilla oil powder treatment was significantly higher than of vehicle treatment for 1, 14, 28 and 56 d. We thereby demonstrated for the first time the utility of Calshell oil powder treatment for effective and sustainable GLP-1 secretion. The Calshell technique is apparently useful as a drug delivery system, since Calshell unsaturated oil powder is protected from gastric acid, reaches enteroendocrine cells in the gastrointestinal tract, and then induces effective incretin secretion.

引用

页码：1021 / 1023

页数：3

共 26 条

[1]

Free fatty acids administered into the colon promote the secretion of glucagon-like peptide-1 and insulin [J].