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A genome screen for multiple sclerosis in Sardinian multiplex families

被引：69
作者：
Coraddu, F
Sawcer, S
D'Alfonso, S
Lai, M
Hensiek, A
Solla, E
Broadley, S
Mancosu, C
Pugliatti, M
Marrosu, MG
Compston, A
机构：
[1] Univ Cagliari, Ctr Diagnosi & Cura Sclerosi Multipla, Osped Binaghi ASL8, I-09100 Cagliari, Italy
[2] Univ Cambridge, Addenbrookes Hosp, Neurol Unit, Cambridge CB2 2QQ, England
[3] Univ Piemonte Orientale A Avogadro, Dept Med Sci, Novara, Italy
[4] Univ Sassari, Neurol Clin, I-07100 Sassari, Italy
来源：
EUROPEAN JOURNAL OF HUMAN GENETICS | 2001年 / 9卷 / 08期
基金：
英国惠康基金;
关键词：
multiple sclerosis; linkage; genome screens; Sardinians;
D O I：
10.1038/sj.ejhg.5200680
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The prevalence of multiple sclerosis in Sardinia is significantly higher than in neighbouring Mediterranean countries, suggesting that the isolated growth of the population has concentrated genetic factors which increase susceptibility to the disease. The distinct HLA association of multiple sclerosis in Sardinia supports this interpretation. We have performed a whole genome screen for linkage in 49 Sardinian multiplex families using 327 markers. Non parametric linkage analysis of these data reveal suggestive linkage in the region of Chr 1q31, Chr 10q23 and Chr 11p15.
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收藏
页码：621 / 626
页数：6
相关论文
共 23 条
  • [1] The genetics of multiple sclerosis: principles, background and updated results of the United Kingdom systematic genome screen
    Chataway, J
    Feakes, R
    Coraddu, F
    Gray, J
    Deans, J
    Fraser, M
    Robertson, N
    Broadley, S
    Jones, H
    Clayton, D
    Goodfellow, P
    Sawcer, S
    Compston, A
    [J]. BRAIN, 1998, 121 : 1869 - 1887
  • [2] A metric map of humans: 23,500 loci in 850 bands
    Collins, A
    Frezal, J
    Teague, J
    Morton, NE
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (25) : 14771 - 14775
  • [3] Linkage analysis of multiple sclerosis with candidate region markers in Sardinian and Continental Italian families
    D'Alfonso, S
    Nisticò, L
    Zavattari, P
    Marrosu, MG
    Murru, R
    Lai, M
    Massacesi, L
    Ballerini, C
    Gestri, D
    Salvetti, M
    Ristori, G
    Bomprezzi, R
    Trojanò, M
    Liguori, M
    Gambi, D
    Quattrone, A
    Fruci, D
    Cucca, F
    Richiardi, PM
    Tosi, R
    [J]. EUROPEAN JOURNAL OF HUMAN GENETICS, 1999, 7 (03) : 377 - 385
  • [4] A GENOME-WIDE SEARCH FOR HUMAN TYPE-1 DIABETES SUSCEPTIBILITY GENES
    DAVIES, JL
    KAWAGUCHI, Y
    BENNETT, ST
    COPEMAN, JB
    CORDELL, HJ
    PRITCHARD, LE
    REED, PW
    GOUGH, SCL
    JENKINS, SC
    PALMER, SM
    BALFOUR, KM
    ROWE, BR
    FARRALL, M
    BARNETT, AH
    BAIN, SC
    TODD, JA
    [J]. NATURE, 1994, 371 (6493) : 130 - 136
  • [5] Genetics of multiple sclerosis
    Dyment, DA
    Sadnovich, AD
    Ebers, GC
    [J]. HUMAN MOLECULAR GENETICS, 1997, 6 (10) : 1693 - 1698
  • [6] A full genome search in multiple sclerosis
    Ebers, GC
    Kukay, K
    Bulman, DE
    Sadovnick, AD
    Rice, G
    Anderson, C
    Armstrong, H
    Cousin, K
    Bell, RB
    Hader, W
    Paty, DW
    Hashimoto, S
    Oger, J
    Duquette, P
    Warren, S
    Gray, T
    OConnor, P
    Nath, A
    Auty, A
    Metz, L
    Francis, G
    Paulseth, JE
    Murray, TJ
    PrysePhillips, W
    Nelson, R
    Freedman, M
    Brunet, D
    Bouchard, JP
    Hinds, D
    Risch, N
    [J]. NATURE GENETICS, 1996, 13 (04) : 472 - 476
  • [7] A test statistic to detect errors in sib-pair relationships
    Ehm, MG
    Wagner, M
    [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 1998, 62 (01) : 181 - 188
  • [8] A complete genomic screen for multiple sclerosis underscores a role for the major histocompatability complex
    Haines, JL
    TerMinassian, M
    Bazyk, A
    Gusella, JF
    Kim, DJ
    Terwedow, H
    PericakVance, MA
    Rimmler, JB
    Haynes, CS
    Roses, AD
    Lee, A
    Shaner, B
    Menold, M
    Seboun, E
    Fitoussi, RP
    Gartioux, C
    Reyes, C
    Ribierre, F
    Gyapay, G
    Weissenbach, J
    Hauser, SL
    Goodkin, DE
    Lincoln, R
    Usuku, K
    GarciaMerino, A
    Gatto, N
    Young, S
    Oksenberg, JR
    [J]. NATURE GENETICS, 1996, 13 (04) : 469 - 471
  • [9] A point mutation in PTPRC is associated with the development of multiple sclerosis
    Jacobsen, M
    Schweer, D
    Ziegler, A
    Gaber, R
    Schock, S
    Schwinzer, R
    Wonigeit, K
    Lindert, RB
    Kantarci, O
    Schaefer-Klein, J
    Schipper, HI
    Oertel, WH
    Heidenreich, F
    Weinshenker, BG
    Sommer, N
    Hemmer, B
    [J]. NATURE GENETICS, 2000, 26 (04) : 495 - 499
  • [10] KRUGLYAK L, 1995, AM J HUM GENET, V57, P439
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