Dopamine D1-like receptor subtypes in the rat kidney:: A microanatomical study

The microanatomical localization of dopamine D-1A and D-1B receptor subtypes was investigated in sections of rat kidney using immunohistochemicals techniques with antidopamine D-1A and D-1B receptor antibodies. Microanatomical analysis was limited to the various components of nephron. Dopamine D-1A receptor immunoreactivity was found primarily in the epithelium of loop of nephron (loop of Henle) and of collecting tubules. A less intense immunoreactivity was observed within proximal and distal convoluted tubules as well as in juxtaglomerular complex. Dopamine D-1A receptor immunoreactivity was found primarily in proximal and distal convoluted tubules and within the juxtaglomerular complex. A less intense immunoreactivity was observed in the epithelium of collecting tubules followed by the loop of nephron. The demonstration of the localization of dopamine D-1A and D-1B receptor subtypes along the nephron may contribute to better define their significance in physiological and pathological conditions.