The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteins - Introduction

被引:670
作者
Hediger, MA
Romero, MF
Peng, JB
Rolfs, A
Takanaga, H
Bruford, EA
机构
[1] Brigham & Womens Hosp, Harvard Inst Med, Membrane Biol Program, Boston, MA 02115 USA
[2] Brigham & Womens Hosp, Harvard Inst Med, Div Renal, Boston, MA 02115 USA
[3] Case Western Reserve Univ, Sch Med, Dept Physiol & Biophys, Cleveland, OH 44106 USA
[4] Univ Alabama, Dept Med, Div Nephrol, Birmingham, AL 35294 USA
[5] Harvard Univ, Sch Med, Harvard Inst Proteom, Cambridge, MA 02141 USA
[6] UCL, Dept Biol, HUGO Gene Nomenclature Comm, London NW1 2HE, England
来源
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 2004年 / 447卷 / 05期
关键词
transporter; carrier; nomenclature; SLC; exchanger; cotransporter; uniporter; ion transport; solute transport; coupled transport; channel; pump; ABC transporter; transport protein; transporter gene;
D O I
10.1007/s00424-003-1192-y
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
The Human Genome Organisation (HUGO) Nomenclature Committee Database provides a list of transporter families of the solute carrier (SLC) gene series (see http://www.gene.ucl.ac.uk/nomenclature/). Currently, it includes 43 families and 298 transporter genes. This special issue features mini-reviews on each of these SLC families written by the experts in each field. A WEB site has been established (http://www.pharmaconference.org/slctable.asp) that gives the latest updates for the SLC families and their members as well as relevant links to gene databases and reviews in the literature. A list of all currently known SLC families, a discussion of additional SLC families and family members as well as a brief summary of non-SLC transporter genes is included in this introduction.
引用
收藏
页码:465 / 468
页数:4
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