Liver fibrosis during an outbreak of acute hepatitis c virus infection in HIV-infected men: A prospective cohort study

被引：80

作者：

Fierer, Daniel S. ^{[2
]}

Uriel, Alison J. ^{[1
]}

Carriero, Damaris C. ^{[1
]}

Klepper, Arielle ^{[1
]}

Dieterich, Douglas T. ^{[1
]}

Mullen, Michael P. ^{[2
]}

Thung, Swan N. ^{[3
]}

Fiel, M. Isabel ^{[3
]}

Branch, Andrea D. ^{[1
]}

机构：

[1] Mt Sinai Sch Med, Dept Med, New York, NY 10029 USA

[2] Mt Sinai Sch Med, Div Infect Dis, New York, NY 10029 USA

[3] Mt Sinai Sch Med, Dept Pathol, New York, NY 10029 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2008年 / 198卷 / 05期

关键词：

D O I：

10.1086/590430

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Outbreaks of acute hepatitis C virus (HCV) infection are occurring in HIV-infected men who have sex with men. We evaluated risk factors and liver histopathology in 11 consecutively enrolled men with newly acquired HCV infection that was diagnosed on the basis of antibody seroconversion, new elevations in alanine aminotransferase level, and wide fluctuations in HCVRNA level. Ten patients reported unprotected anal intercourse, and 7 reported "club-drug" use, including methamphetamine. Liver biopsy showed moderately advanced fibrosis (Scheuer stage 2) in 9 patients (82%). No cause of liver damage other than acute HCV infection was identified. The specific pathways leading to periportal fibrosis in HIV-infected men with newly acquired HCV infection require investigation.

引用

页码：683 / 686

页数：4

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