Failure of cidofovir therapy in progressive multifocal leukoencephalopathy unrelated to human immunodeficiency virus

被引：19

作者：

Houston, S ^{[1
]}

Roberts, N ^{[1
]}

Mashinter, L ^{[1
]}

机构：

[1] Univ Alberta Hosp, Dept Med, Walter Mackenzie Ctr 2E4 11, Edmonton, AB T6G 2B7, Canada

来源：

CLINICAL INFECTIOUS DISEASES | 2001年 / 32卷 / 01期

关键词：

D O I：

10.1086/317539

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We describe the first reported human immunodeficiency virus (HIV)-seronegative patient treated with cidofovir for progressive multifocal leukoencephalopathy (PML). Marked clinical and radiological progression of PML occurred during cidofovir therapy. The improvement observed during cidofovir therapy of HIV-infected patients may be due to the effect of concomitant antiretroviral therapy rather than cidofovir.

引用

页码：150 / 152

页数：3

共 12 条

[1] Activities of various compounds against murine and primate polyomaviruses [J].

Andrei, G ;

Snoeck, R ;

Vandeputte, M ;

DeClercq, E .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (03) :587-593

[2] Successful resolution of progressive multifocal leukoencephalopathy after combination therapy with cidofovir and cytosine arabinoside [J].

Blick, G ;

Whiteside, M ;

Griegor, P ;

Hopkins, U ;

Garton, T ;

LaGravinese, L .

CLINICAL INFECTIOUS DISEASES, 1998, 26 (01) :191-192

[3] Response to cidofovir after failure of antiretroviral therapy alone in AIDS-associated progressive multifocal leukoencephalopathy [J].

De Luca, A ;

Fantoni, M ;

Tartaglione, T ;

Antinori, A .

NEUROLOGY, 1999, 52 (04) :891-892

[4]

Dodge R T, 1999, J Assoc Nurses AIDS Care, V10, P70, DOI 10.1016/S1055-3290(06)60311-7

[5] Progressive multifocal leukoencephalopathy: Improved survival of human immunodeficiency virus-infected patients in the protease inhibitor era [J].

Dworkin, MS ;

Wan, PCT ;

Hanson, DL ;

Jones, JL .

JOURNAL OF INFECTIOUS DISEASES, 1999, 180 (03) :621-625

[6] Prolonged survival without neurological improvement in patients with AIDS-related progressive multifocal leukoencephalopathy on potent combined antiretroviral therapy [J].

Gasnault, J ;

Taoufik, Y ;

Goujard, C ;

Kousignian, P ;

Abbed, K ;

Boue, F ;

Dussaix, E ;

Delfraissy, JF .

JOURNAL OF NEUROVIROLOGY, 1999, 5 (04) :421-429

[7] Failure of cytarabine in progressive multifocal leukoencephalopathy associated with human immunodeficiency virus infection [J].

Hall, CD ;

Dafni, U ;

Simpson, D ;

Clifford, D ;

Wetherill, PE ;

Cohen, B ;

McArthur, J ;

Hollander, H ;

Yainnoutsos, C ;

Major, E ;

Millar, L ;

Timpone, J .

NEW ENGLAND JOURNAL OF MEDICINE, 1998, 338 (19) :1345-1351

[8]

Happe S, 1999, NERVENARZT, V70, P935, DOI 10.1007/s001150050601

[9] Monitoring the response of AIDS-related progressive multifocal leukoencephalopathy to HAART and cidofovir by PCR for JC virus DNA in the CSF [J].

Meylan, PRA ;

Vuadens, P ;

Maeder, P ;

Sahli, R ;

Tagan, MC .

EUROPEAN NEUROLOGY, 1999, 41 (03) :172-174

[10] Treatment of AIDS-associated progressive multifocal leukoencephalopathy with highly active antiretroviral therapy [J].

Miralles, P ;

Berenguer, J ;

Garcia de Viedma, D ;

Padilla, B ;

Cosin, J ;

de Quirós, JCLB ;

Muñoz, L ;

Moreno, S ;

Bouza, E .

AIDS, 1998, 12 (18) :2467-2472

← 1 2 →