Reproducibility of direct quantitative measures of cortical bone microarchitecture of the distal radius and tibia by HR-pQCT

被引:379
作者
Burghardt, Andrew J. [1 ]
Buie, Helen R. [2 ]
Laib, Andres [3 ]
Majumdar, Sharmila [1 ]
Boyd, Steven K. [2 ]
机构
[1] Univ Calif San Francisco, Dept Radiol & Biomed Imaging, Musculoskeletal Quantitat Imaging Res Grp, San Francisco, CA 94158 USA
[2] Univ Calgary, Dept Mech & Mfg Engn, Schulich Sch Engn, Calgary, AB, Canada
[3] Scanco Med AG, Bruttisellen, Switzerland
基金
加拿大健康研究院;
关键词
HR-pQCT; Cortical bone; Porosity; Segmentation; Osteoporosis; Microcomputed tomography; MicroCT; Reproducibility; IN-VIVO ASSESSMENT; COMPUTED-TOMOGRAPHY; POSTMENOPAUSAL WOMEN; TRABECULAR BONE; INTRACORTICAL POROSITY; FRACTURE; OSTEOPOROSIS; ACCURACY; QUALITY; IMAGES;
D O I
10.1016/j.bone.2010.05.034
中图分类号
R5 [内科学];
学科分类号
100201 [内科学];
摘要
Quantitative cortical microarchitectural end points are important for understanding structure-function relations in the context of fracture risk and therapeutic efficacy. This technique study details new image-processing methods to automatically segment and directly quantify cortical density, geometry, and microarchitecture from HR-pQCT images of the distal radius and tibia. An automated segmentation technique was developed to identify the periosteal and endosteal margins of the distal radius and tibia and detect intracortical pore space morphologically consistent with Haversian canals. The reproducibility of direct quantitative cortical bone indices based on this method was assessed in a pooled data set of 56 subjects with two repeat acquisitions for each site. The in vivo precision error was characterized using root mean square coefficient of variation (RMSCV%) from which the least significant change (LSC) was calculated. Bland-Altman plots were used to characterize bias in the precision estimates. The reproducibility of cortical density and cross-sectional area measures was high (RMSCV <1% and <1.5%, respectively) with good agreement between young and elder medians. The LSC for cortical porosity (Ct.Po) was somewhat smaller in the radius (0.58%) compared with the distal tibia (0.84%) and significantly different between young and elder medians in the distal tibia (LSC: 0.75% vs. 0.92%, p<0.001). The LSC for pore diameter and distribution (Po.Dm and Po.Dm.SD) ranged between 15 and 23 pm. Bland-Altman analysis revealed moderate bias for integral measures of area and volume but not for density or microarchitecture. This study indicates that HR-pQCT measures of cortical bone density and architecture can be measured in vivo with high reproducibility and limited bias across a biologically relevant range of values. The results of this study provide informative data for the design of future clinical studies of bone quality. (C) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码:519 / 528
页数:10
相关论文
共 29 条
[1]
Borah B., 2009, J Bone Miner Res
[2]
Risedronate Reduces Intracortical Porosity in Women With Osteoporosis [J].
Borah, Babul ;
Dufresne, Tom ;
Nurre, Joe ;
Phipps, Roger ;
Chmielewski, Paula ;
Wagner, Leigh ;
Lundy, Mark ;
Bouxsein, Mary ;
Zebaze, Roger ;
Seeman, Ego .
JOURNAL OF BONE AND MINERAL RESEARCH, 2010, 25 (01) :41-47
[3]
In vivo assessment of trabecular bone microarchitecture by high-resolution peripheral quantitative computed tomography [J].
Boutroy, S ;
Bouxsein, ML ;
Munoz, F ;
Delmas, PD .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 90 (12) :6508-6515
[4]
Finite element analysis based on in vivo HR-pQCT images of the distal radius is associated with wrist fracture in postmenopausal women [J].
Boutroy, Stephanie ;
Van Rietbergen, Bert ;
Sornay-Rendu, Elisabeth ;
Munoz, Francoise ;
Bouxsein, Mary L. ;
Delmas, Pierre D. .
JOURNAL OF BONE AND MINERAL RESEARCH, 2008, 23 (03) :392-399
[5]
Automatic segmentation of cortical and trabecular compartments based on a dual threshold technique for in vivo micro-CT bone analysis [J].
Buie, Helen R. ;
Campbell, Graeme M. ;
Klinck, R. Joshua ;
MacNeil, Joshua A. ;
Boyd, Steven K. .
BONE, 2007, 41 (04) :505-515
[6]
Quantitative assessment of bone tissue mineralization with polychromatic micro-computed tomography [J].
Burghardt, Andrew J. ;
Kazakia, Galateia J. ;
Laib, Andres ;
Majumdar, Sharmila .
CALCIFIED TISSUE INTERNATIONAL, 2008, 83 (02) :129-138
[7]
A local adaptive threshold strategy for high resolution peripheral quantitative computed tomography of trabecular bone [J].
Burghardt, Andrew J. ;
Kazakia, Galateia J. ;
Majumdar, Sharmila .
ANNALS OF BIOMEDICAL ENGINEERING, 2007, 35 (10) :1678-1686
[8]
Age- and Gender-Related Differences in the Geometric Properties and Biomechanical Significance of Intracortical Porosity in the Distal Radius and Tibia [J].
Burghardt, Andrew J. ;
Kazakia, Galateia J. ;
Ramachandran, Sweta ;
Link, Thomas M. ;
Majumdar, Sharmila .
JOURNAL OF BONE AND MINERAL RESEARCH, 2010, 25 (05) :983-993
[9]
The effects of geometric and threshold definitions on cortical bone metrics assessed by in vivo high-resolution peripheral quantitative computed tomography [J].
Davis, Kevin A. ;
Burghardt, Andrew J. ;
Link, Thomas M. ;
Majumdar, Sharmila .
CALCIFIED TISSUE INTERNATIONAL, 2007, 81 (05) :364-371
[10]
PRACTICAL CONE-BEAM ALGORITHM [J].
FELDKAMP, LA ;
DAVIS, LC ;
KRESS, JW .
JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION, 1984, 1 (06) :612-619