Expression of galanin receptor messenger RNAs in different regions of the rat gastrointestinal tract

被引：20

作者：

Anselmi, L

Lakhter, A

Hirano, AA

Tonini, M

Sternini, C

机构：

[1] VAGLAHS, CURE Digest Dis Res Ctr, Div Digest Dis, Los Angeles, CA 90073 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurobiol, Los Angeles, CA 90095 USA

[4] Vet Adm Greater Los Angeles Healthcare Syst, Los Angeles, CA 90073 USA

[5] Univ Pavia, Dept Physiol & Pharmacol Sci, I-27100 Pavia, Italy

来源：

PEPTIDES | 2005年 / 26卷 / 05期

关键词：

real-time RT-PCR; intestine; stomach; enteric nervous system;

D O I：

10.1016/j.peptides.2004.12.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Galanin effects are mediated by three G-protein-coupled receptors: galanin receptor 1 (GalR1), GalR2 and GalR3. We quantified mRNA levels of GalR1, GalR2 and GalR3 in the rat stomach, small and large intestine using real-time RT-PCR. All three GalR mRNAs were detected throughout the gut at different levels. GalR1 and GalR2 mRNA levels were higher in the large than in the small intestine. GalR2 mRNA was most abundant in the stomach. GalR3 mRNA levels were generally quite low. The differential regional distribution of GalRs suggests that the complex effects of galanin in the gut are the result of activating multiple receptor subtypes, whose density, subtype and signaling vary along the gastrointestinal tract. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：815 / 819

页数：5

共 28 条

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