Sodium 2-ethylhexanoate: A mild acid scavenger useful in acylation of amines

被引:6
作者
Fitt, J [1 ]
Prasad, K [1 ]
Repic, O [1 ]
Blacklock, TJ [1 ]
机构
[1] Novartis Pharmaceut Corp, Proc R&D, Chem & Analyt Dev, E Hanover, NJ 07936 USA
关键词
D O I
10.1016/S0040-4039(98)01546-9
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A highly useful method for the acylation of amines with acid chlorides utilizing sodium 2-ethylhexanoate as the base is described. This procedure is superior to the Schonen-Baumann conditions whenever the product is water soluble. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:6991 / 6992
页数:2
相关论文
共 3 条
  • [1] CABRE J, 1997, Patent No. 9715579
  • [2] NYCE PL, 1991, SYNTHESIS-STUTTGART, P571
  • [3] Pessa A., 1997, U.S. Patent, Patent No. [5,625,058, 5625058]