Sodium 2-ethylhexanoate: A mild acid scavenger useful in acylation of amines

被引：6

作者：

Fitt, J ^{[1
]}

Prasad, K ^{[1
]}

Repic, O ^{[1
]}

Blacklock, TJ ^{[1
]}

机构：

[1] Novartis Pharmaceut Corp, Proc R&D, Chem & Analyt Dev, E Hanover, NJ 07936 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 39期

关键词：

D O I：

10.1016/S0040-4039(98)01546-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly useful method for the acylation of amines with acid chlorides utilizing sodium 2-ethylhexanoate as the base is described. This procedure is superior to the Schonen-Baumann conditions whenever the product is water soluble. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：6991 / 6992

页数：2