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Polyglutamines stop traffic: Axonal transport as a common target in neurodegenerative diseases
被引:24
作者:

Feany, MB
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Neuropathol,Dept Pathol, Boston, MA 02115 USA

La Spada, AR
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Neuropathol,Dept Pathol, Boston, MA 02115 USA
机构:
[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Neuropathol,Dept Pathol, Boston, MA 02115 USA
[2] Univ Washington, Med Ctr, Dept Lab Med, Div Med Genet,Div Neurogenet, Seattle, WA 98195 USA
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D O I:
10.1016/S0896-6273(03)00600-7
中图分类号:
Q189 [神经科学];
学科分类号:
071006 ;
摘要:
In this issue of Neuron, two papers provide evidence that polyglutamine (polyQ) proteins disrupt axonal transport. Gunawardena et al. show that normal levels of huntingtin are required for proper axonal transport in Drosophila. In addition, expression of expanded polyQ proteins disrupts axonal transport in larval neurons. Szebenyi and colleagues find that polyQ proteins directly inhibit fast axonal transport using axoplasm from the squid giant axon and suggest that axonal transport defects may be a common feature of polyQ disease pathogenesis.
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- [1] Pro-apoptotic BH3-only Bcl-2 family members in vertebrate model organisms suitable for genetic experimentation[J]. CELL DEATH AND DIFFERENTIATION, 2002, 9 (11) : 1163 - 1166Coultas, L论文数: 0 引用数: 0 h-index: 0机构: Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, AustraliaHuang, DCS论文数: 0 引用数: 0 h-index: 0机构: Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, AustraliaAdams, JM论文数: 0 引用数: 0 h-index: 0机构: Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, AustraliaStrasser, A论文数: 0 引用数: 0 h-index: 0机构: Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia
- [2] Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice[J]. NATURE GENETICS, 2000, 26 (03) : 300 - 306Dragatsis, I论文数: 0 引用数: 0 h-index: 0机构: Columbia Univ, Dept Pathol, New York, NY USALevine, MS论文数: 0 引用数: 0 h-index: 0机构: Columbia Univ, Dept Pathol, New York, NY USAZeitlin, S论文数: 0 引用数: 0 h-index: 0机构: Columbia Univ, Dept Pathol, New York, NY USA
- [3] Disruption of axonal transport by loss of huntingtin or expression of pathogenic PolyQ proteins in Drosophila[J]. NEURON, 2003, 40 (01) : 25 - 40Gunawardena, S论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Diego, Dept Cellular & Mol Physiol, La Jolla, CA 92093 USAHer, LS论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Diego, Dept Cellular & Mol Physiol, La Jolla, CA 92093 USABrusch, RG论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Diego, Dept Cellular & Mol Physiol, La Jolla, CA 92093 USALaymon, RA论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Diego, Dept Cellular & Mol Physiol, La Jolla, CA 92093 USANiesman, IR论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Diego, Dept Cellular & Mol Physiol, La Jolla, CA 92093 USAGordesky-Gold, B论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Diego, Dept Cellular & Mol Physiol, La Jolla, CA 92093 USASintasath, L论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Diego, Dept Cellular & Mol Physiol, La Jolla, CA 92093 USABonini, NM论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Diego, Dept Cellular & Mol Physiol, La Jolla, CA 92093 USAGoldstein, LSB论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Diego, Dept Cellular & Mol Physiol, La Jolla, CA 92093 USA Univ Calif San Diego, Dept Cellular & Mol Physiol, La Jolla, CA 92093 USA
- [4] Mutations in dynein link motor neuron degeneration to defects in retrograde transport[J]. SCIENCE, 2003, 300 (5620) : 808 - 812Hafezparast, M论文数: 0 引用数: 0 h-index: 0机构: Ingenium Pharmaceut AG, D-82152 Martinsried, GermanyKlocke, R论文数: 0 引用数: 0 h-index: 0机构: Ingenium Pharmaceut AG, D-82152 Martinsried, GermanyRuhrberg, C论文数: 0 引用数: 0 h-index: 0机构: Ingenium Pharmaceut AG, D-82152 Martinsried, GermanyMarquardt, A论文数: 0 引用数: 0 h-index: 0机构: Ingenium Pharmaceut AG, D-82152 Martinsried, GermanyAhmad-Annuar, A论文数: 0 引用数: 0 h-index: 0机构: Ingenium Pharmaceut AG, D-82152 Martinsried, GermanyBowen, S论文数: 0 引用数: 0 h-index: 0机构: Ingenium Pharmaceut AG, D-82152 Martinsried, GermanyLalli, G论文数: 0 引用数: 0 h-index: 0机构: Ingenium Pharmaceut AG, D-82152 Martinsried, GermanyWitherden, AS论文数: 0 引用数: 0 h-index: 0机构: Ingenium Pharmaceut AG, D-82152 Martinsried, GermanyHummerich, H论文数: 0 引用数: 0 h-index: 0机构: Ingenium Pharmaceut AG, D-82152 Martinsried, GermanyNicholson, S论文数: 0 引用数: 0 h-index: 0机构: Ingenium Pharmaceut AG, D-82152 Martinsried, GermanyMorgan, PJ论文数: 0 引用数: 0 h-index: 0机构: Ingenium Pharmaceut AG, D-82152 Martinsried, GermanyOozageer, R论文数: 0 引用数: 0 h-index: 0机构: Ingenium Pharmaceut AG, D-82152 Martinsried, GermanyPriestley, JV论文数: 0 引用数: 0 h-index: 0机构: Ingenium Pharmaceut AG, D-82152 Martinsried, GermanyAverill, S论文数: 0 引用数: 0 h-index: 0机构: Ingenium Pharmaceut AG, D-82152 Martinsried, GermanyKing, VR论文数: 0 引用数: 0 h-index: 0机构: Ingenium Pharmaceut AG, D-82152 Martinsried, GermanyBall, S论文数: 0 引用数: 0 h-index: 0机构: Ingenium Pharmaceut AG, D-82152 Martinsried, GermanyPeters, J论文数: 0 引用数: 0 h-index: 0机构: Ingenium Pharmaceut AG, D-82152 Martinsried, GermanyToda, T论文数: 0 引用数: 0 h-index: 0机构: Ingenium Pharmaceut AG, D-82152 Martinsried, GermanyYamamoto, A论文数: 0 引用数: 0 h-index: 0机构: Ingenium Pharmaceut AG, D-82152 Martinsried, GermanyHiraoka, Y论文数: 0 引用数: 0 h-index: 0机构: Ingenium Pharmaceut AG, D-82152 Martinsried, GermanyAugustin, M论文数: 0 引用数: 0 h-index: 0机构: Ingenium Pharmaceut AG, D-82152 Martinsried, GermanyKorthaus, D论文数: 0 引用数: 0 h-index: 0机构: Ingenium Pharmaceut AG, D-82152 Martinsried, GermanyWattler, S论文数: 0 引用数: 0 h-index: 0机构: Ingenium Pharmaceut AG, D-82152 Martinsried, GermanyWabnitz, P论文数: 0 引用数: 0 h-index: 0机构: Ingenium Pharmaceut AG, D-82152 Martinsried, GermanyDickneite, C论文数: 0 引用数: 0 h-index: 0机构: Ingenium Pharmaceut AG, D-82152 Martinsried, GermanyLampel, S论文数: 0 引用数: 0 h-index: 0机构: Ingenium Pharmaceut AG, D-82152 Martinsried, GermanyBoehme, F论文数: 0 引用数: 0 h-index: 0机构: Ingenium Pharmaceut AG, D-82152 Martinsried, GermanyPeraus, G论文数: 0 引用数: 0 h-index: 0机构: Ingenium Pharmaceut AG, D-82152 Martinsried, GermanyPopp, A论文数: 0 引用数: 0 h-index: 0机构: Ingenium Pharmaceut AG, D-82152 Martinsried, GermanyRudelius, M论文数: 0 引用数: 0 h-index: 0机构: Ingenium Pharmaceut AG, D-82152 Martinsried, GermanySchlegel, J论文数: 0 引用数: 0 h-index: 0机构: Ingenium Pharmaceut AG, D-82152 Martinsried, GermanyFuchs, H论文数: 0 引用数: 0 h-index: 0机构: Ingenium Pharmaceut AG, D-82152 Martinsried, Germanyde Angelis, MH论文数: 0 引用数: 0 h-index: 0机构: Ingenium Pharmaceut AG, D-82152 Martinsried, GermanySchiavo, G论文数: 0 引用数: 0 h-index: 0机构: Ingenium Pharmaceut AG, D-82152 Martinsried, GermanyShima, DT论文数: 0 引用数: 0 h-index: 0机构: Ingenium Pharmaceut AG, D-82152 Martinsried, GermanyRuss, AP论文数: 0 引用数: 0 h-index: 0机构: Ingenium Pharmaceut AG, D-82152 Martinsried, GermanyStumm, G论文数: 0 引用数: 0 h-index: 0机构: Ingenium Pharmaceut AG, D-82152 Martinsried, GermanyMartin, JE论文数: 0 引用数: 0 h-index: 0机构: Ingenium Pharmaceut AG, D-82152 Martinsried, GermanyFisher, EMC论文数: 0 引用数: 0 h-index: 0机构: Ingenium Pharmaceut AG, D-82152 Martinsried, Germany
- [5] Polyglutamines placed into context[J]. NEURON, 2003, 38 (05) : 681 - 684La Spada, AR论文数: 0 引用数: 0 h-index: 0机构: Univ Washington, Ctr Med, Dept Lab Med, Div Med Genet Med, Seattle, WA 98195 USA Univ Washington, Ctr Med, Dept Lab Med, Div Med Genet Med, Seattle, WA 98195 USATaylor, JP论文数: 0 引用数: 0 h-index: 0机构: Univ Washington, Ctr Med, Dept Lab Med, Div Med Genet Med, Seattle, WA 98195 USA
- [6] Disruption of dynein/dynactin inhibits axonal transport in motor neurons causing late-onset progressive degeneration[J]. NEURON, 2002, 34 (05) : 715 - 727LaMonte, BH论文数: 0 引用数: 0 h-index: 0机构: Univ Penn, Sch Med, Dept Physiol, Philadelphia, PA 19104 USAWallace, KE论文数: 0 引用数: 0 h-index: 0机构: Univ Penn, Sch Med, Dept Physiol, Philadelphia, PA 19104 USAHolloway, BA论文数: 0 引用数: 0 h-index: 0机构: Univ Penn, Sch Med, Dept Physiol, Philadelphia, PA 19104 USAShelly, SS论文数: 0 引用数: 0 h-index: 0机构: Univ Penn, Sch Med, Dept Physiol, Philadelphia, PA 19104 USAAscaño, J论文数: 0 引用数: 0 h-index: 0机构: Univ Penn, Sch Med, Dept Physiol, Philadelphia, PA 19104 USATokito, M论文数: 0 引用数: 0 h-index: 0机构: Univ Penn, Sch Med, Dept Physiol, Philadelphia, PA 19104 USAVan Winkle, T论文数: 0 引用数: 0 h-index: 0机构: Univ Penn, Sch Med, Dept Physiol, Philadelphia, PA 19104 USAHowland, DS论文数: 0 引用数: 0 h-index: 0机构: Univ Penn, Sch Med, Dept Physiol, Philadelphia, PA 19104 USAHolzbaur, ELF论文数: 0 引用数: 0 h-index: 0机构: Univ Penn, Sch Med, Dept Physiol, Philadelphia, PA 19104 USA
- [7] Huntingtin aggregate-associated axonal degeneration is an early pathological event in Huntington's disease mice[J]. JOURNAL OF NEUROSCIENCE, 2001, 21 (21) : 8473 - 8481Li, H论文数: 0 引用数: 0 h-index: 0机构: Emory Univ, Sch Med, Dept Genet, Atlanta, GA 30322 USALi, SH论文数: 0 引用数: 0 h-index: 0机构: Emory Univ, Sch Med, Dept Genet, Atlanta, GA 30322 USAYu, ZX论文数: 0 引用数: 0 h-index: 0机构: Emory Univ, Sch Med, Dept Genet, Atlanta, GA 30322 USAShebourne, P论文数: 0 引用数: 0 h-index: 0机构: Emory Univ, Sch Med, Dept Genet, Atlanta, GA 30322 USALi, XJ论文数: 0 引用数: 0 h-index: 0机构: Emory Univ, Sch Med, Dept Genet, Atlanta, GA 30322 USA
- [8] Mutant dynactin in motor neuron disease[J]. NATURE GENETICS, 2003, 33 (04) : 455 - 456Puls, I论文数: 0 引用数: 0 h-index: 0机构: NINDS, Neurogenet Branch, NIH, Bethesda, MD 20892 USA NINDS, Neurogenet Branch, NIH, Bethesda, MD 20892 USAJonnakuty, C论文数: 0 引用数: 0 h-index: 0机构: NINDS, Neurogenet Branch, NIH, Bethesda, MD 20892 USALaMonte, BH论文数: 0 引用数: 0 h-index: 0机构: NINDS, Neurogenet Branch, NIH, Bethesda, MD 20892 USAHolzbaur, ELF论文数: 0 引用数: 0 h-index: 0机构: NINDS, Neurogenet Branch, NIH, Bethesda, MD 20892 USATokito, M论文数: 0 引用数: 0 h-index: 0机构: NINDS, Neurogenet Branch, NIH, Bethesda, MD 20892 USAMann, E论文数: 0 引用数: 0 h-index: 0机构: NINDS, Neurogenet Branch, NIH, Bethesda, MD 20892 USAFloeter, MK论文数: 0 引用数: 0 h-index: 0机构: NINDS, Neurogenet Branch, NIH, Bethesda, MD 20892 USABidus, K论文数: 0 引用数: 0 h-index: 0机构: NINDS, Neurogenet Branch, NIH, Bethesda, MD 20892 USADrayna, D论文数: 0 引用数: 0 h-index: 0机构: NINDS, Neurogenet Branch, NIH, Bethesda, MD 20892 USAOh, SJ论文数: 0 引用数: 0 h-index: 0机构: NINDS, Neurogenet Branch, NIH, Bethesda, MD 20892 USABrown, RH论文数: 0 引用数: 0 h-index: 0机构: NINDS, Neurogenet Branch, NIH, Bethesda, MD 20892 USALudlow, CL论文数: 0 引用数: 0 h-index: 0机构: NINDS, Neurogenet Branch, NIH, Bethesda, MD 20892 USAFischbeck, KH论文数: 0 引用数: 0 h-index: 0机构: NINDS, Neurogenet Branch, NIH, Bethesda, MD 20892 USA
- [9] Polyglutamine pathogenesis: Emergence of unifying mechanisms for Huntington's disease and related disorders[J]. NEURON, 2002, 35 (05) : 819 - 822Ross, CA论文数: 0 引用数: 0 h-index: 0机构: Johns Hopkins Univ, Sch Med, Dept Psychiat, Div Neurobiol, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Dept Psychiat, Div Neurobiol, Baltimore, MD 21205 USA
- [10] Neuropathogenic forms of huntingtin and androgen receptor inhibit fast axonal transport[J]. NEURON, 2003, 40 (01) : 41 - 52Szebenyi, G论文数: 0 引用数: 0 h-index: 0机构: Univ Illinois, Dept Anat & Cell Biol, Chicago, IL 60612 USAMorfini, GA论文数: 0 引用数: 0 h-index: 0机构: Univ Illinois, Dept Anat & Cell Biol, Chicago, IL 60612 USABabcock, A论文数: 0 引用数: 0 h-index: 0机构: Univ Illinois, Dept Anat & Cell Biol, Chicago, IL 60612 USAGould, M论文数: 0 引用数: 0 h-index: 0机构: Univ Illinois, Dept Anat & Cell Biol, Chicago, IL 60612 USASelkoe, K论文数: 0 引用数: 0 h-index: 0机构: Univ Illinois, Dept Anat & Cell Biol, Chicago, IL 60612 USAStenoien, DL论文数: 0 引用数: 0 h-index: 0机构: Univ Illinois, Dept Anat & Cell Biol, Chicago, IL 60612 USAYoung, M论文数: 0 引用数: 0 h-index: 0机构: Univ Illinois, Dept Anat & Cell Biol, Chicago, IL 60612 USAFaber, PW论文数: 0 引用数: 0 h-index: 0机构: Univ Illinois, Dept Anat & Cell Biol, Chicago, IL 60612 USAMacDonald, ME论文数: 0 引用数: 0 h-index: 0机构: Univ Illinois, Dept Anat & Cell Biol, Chicago, IL 60612 USAMcPhaul, MJ论文数: 0 引用数: 0 h-index: 0机构: Univ Illinois, Dept Anat & Cell Biol, Chicago, IL 60612 USABrady, ST论文数: 0 引用数: 0 h-index: 0机构: Univ Illinois, Dept Anat & Cell Biol, Chicago, IL 60612 USA Univ Illinois, Dept Anat & Cell Biol, Chicago, IL 60612 USA