Three common assumptions about ocular blood flow and glaucoma

Although substantial indirect evidence exists to link altered ocular blood flow to glaucoma, it must be remembered that the validity of investigations in this area depends on acceptance of three basic assumptions: 1) ischemia directly causes or increases the susceptibility of the optic nerve to glaucomatous damage; 2) optic nerve vascular anatomy and physiology allows identification of the critical vascular beds in optic nerve disease; and 3) current measurement techniques provide the ability to monitor important vascular beds. The hypotheses underlying these assumptions are examined. (C) 2001 by Elsevier Science Inc. All rights reserved.