The nucleolus: a site of ribonucleoprotein maturation

被引：96

作者：

Gerbi, SA ^{[1
]}

Borovjagin, AV ^{[1
]}

Lange, TS ^{[1
]}

机构：

[1] Brown Univ, Dept Mol Biol Cell Biol & Biochem, Div Biol & Med, JW Wilson Lab, Providence, RI 02912 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2003年 / 15卷 / 03期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

D O I：

10.1016/S0955-0674(03)00049-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The nucleolus is the site of ribosomal RNA synthesis, processing and ribosome maturation. Various small ribonucleoproteins also undergo maturation in the nucleolus, involving RNA modification and RNA-protein assembly. Such steps and other activities of small ribonucleoproteins also take place in Cajal (coiled) bodies. Events of ribosome biogenesis are found solely-in the nucleolus, which is the final destination of small nucleolar RNAs after their traffic through Cajal bodies. However, nucleoli are just a stopping point in the intricate cellular traffic for small nuclear RNAs and other ribonucleoproteins.

引用

页码：318 / 325

页数：8

共 57 条

[21] Functional base-pairing interaction between highly conserved elements of U3 small nucleolar RNA and the small ribosomal subunit RNA [J].