Stem Cells for Neonatal Brain Disorders

被引：89

作者：

Ahn, So Yoon ^{[1
]}

Chang, Yun Sil ^{[1
]}

Park, Won Soon ^{[1
]}

机构：

[1] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Pediat, 81 Irwon Ro, Seoul 135710, South Korea

来源：

NEONATOLOGY | 2016年 / 109卷 / 04期

关键词：

Mesenchymal stem cells; Cell transplantation; Infant newborn; Intraventricular hemorrhage; Hypoxic-ischemic encephalopathy; Neonatal stroke; UMBILICAL-CORD BLOOD; HYPOXIC-ISCHEMIC ENCEPHALOPATHY; BONE-MARROW; INTRAVENTRICULAR HEMORRHAGE; ADIPOSE-TISSUE; LUNG INJURY; TRANSPLANTATION; THERAPY; INFANTS; STROKE;

D O I：

10.1159/000111905

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Despite recent advances in neonatal intensive care medicine, neonatal brain injury resulting from intraventricular hemorrhage or hypoxic-ischemic encephalopathy remains a major cause of neonatal mortality and neurologic morbidities in survivors. Several studies have indicated that stem cell therapy is a promising novel therapy for neonatal brain injury resulting from these disorders. This review summarizes recent advances in stem cell research for treating neonatal brain injury due to intraventricular hemorrhage or hypoxicischemic encephalopathy with a particular focus on preclinical data, covering important issues for clinical translation such as optimal cell type, route, dose and timing of stem cell therapy, and translation of these preclinical results into a clinical trial. (C) 2016 S. Karger AG, Basel

引用

收藏

页码：377 / 383

页数：7

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