Fluorinated ketene dithioacetals 6.: Synthesis of α-trifluoromethyl-γ-lactams from bis(ethylsulfanyl) (tetrafluoroethylidene)methane

被引：16

作者：

Hénin, B ^{[1
]}

Huot, JF ^{[1
]}

Portella, C ^{[1
]}

机构：

[1] Fac Sci Reims, Assoc CNRS UMR 6519, Lab React Select & Applicat, F-51687 Reims 2, France

来源：

JOURNAL OF FLUORINE CHEMISTRY | 2001年 / 107卷 / 02期

关键词：

organofluorine; trifluoromethyl; ketenedithioacetal; gamma-lactam;

D O I：

10.1016/S0022-1139(00)00371-7

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A method is proposed for the synthesis of alpha -trifluoromethyl-gamma -lactams (3-trifluoromethyl pyrrolidin-2-ones) by reductive amination of a gamma -keto-alpha -trifluoromethyl thiol ester. The latter is prepared in high yield from the perfluoroketene dithioacetal obtained from perfluoropropanal hydrate. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：281 / 283

页数：3

共 13 条

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