Construction of centrosomes and spindle poles by molecular motor-driven assembly of protein particles

被引：57

作者：

Zimmerman, W ^{[1
]}

Doxsey, SJ ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USA

来源：

TRAFFIC | 2000年 / 1卷 / 12期

关键词：

centrosome; MTOC; spindle pole; pericentrin; PCM-1; NuMA; dynein; assembly;

D O I：

10.1034/j.1600-0854.2000.011202.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Centrosomes and other microtubule organizing centers are the largest non-membranous organelles in most cells. This morphologically diverse class of organelles shares a common ability to nucleate and organize microtubules in interphase and participates in the formation of mitotic spindles during cell division. This review summarizes recent evidence suggesting that assembly of centrosomes and mitotic spindle poles require transport of large protein particles along microtubules by the molecular motor cytoplasmic dynein.

引用

页码：927 / 934

页数：8

共 69 条

[1]

Balczon R, 1999, CELL MOTIL CYTOSKEL, V42, P60, DOI 10.1002/(SICI)1097-0169(1999)42:1<60::AID-CM6>3.3.CO

[2]

2-Z

[3] PCM-1, A 228-KD CENTROSOME AUTOANTIGEN WITH A DISTINCT CELL-CYCLE DISTRIBUTION [J].

BALCZON, R ;

BAO, LM ;

ZIMMER, WE .

JOURNAL OF CELL BIOLOGY, 1994, 124 (05) :783-793

[4] DISSOCIATION OF CENTROSOME REPLICATION EVENTS FROM CYCLES OF DNA-SYNTHESIS AND MITOTIC DIVISION IN HYDROXYUREA-ARRESTED CHINESE-HAMSTER OVARY CELLS [J].

BALCZON, R ;

BAO, LM ;

ZIMMER, WE ;

BROWN, K ;

ZINKOWSKI, RP ;

BRINKLEY, BR .

JOURNAL OF CELL BIOLOGY, 1995, 130 (01) :105-115

[5] The travels of mRNAs through all cells large and small [J].

Bassell, GJ ;

Oleynikov, Y ;

Singer, RH .

FASEB JOURNAL, 1999, 13 (03) :447-454

[6] Phosphorylation by p34(cdc2) protein kinase regulates binding of the kinesin-related motor HsEg5 to the dynactin subunit p150(Glued) [J].

Blangy, A ;

Arnaud, L ;

Nigg, EA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (31) :19418-19424

[7] Centriole disassembly in vivo and its effect on centrosome structure and function in vertebrate cells [J].

Bobinnec, Y ;

Khodjakov, A ;

Mir, LM ;

Rieder, CL ;

Eddé, B ;

Bornens, M .

JOURNAL OF CELL BIOLOGY, 1998, 143 (06) :1575-1589

[8]

Brinkley B.R., 1970, ADV CELL BIOL, V1, P119

[9] Overexpression of the dynamitin (p50) subunit of the dynactin complex disrupts dynein-dependent maintenance of membrane organelle distribution [J].

Burkhardt, JK ;

Echeverri, CJ ;

Nilsson, T ;

Vallee, RB .

JOURNAL OF CELL BIOLOGY, 1997, 139 (02) :469-484

[10] SUPERRESOLUTION 3-DIMENSIONAL IMAGES OF FLUORESCENCE IN CELLS WITH MINIMAL LIGHT EXPOSURE [J].

CARRINGTON, WA ;

LYNCH, RM ;

MOORE, EDW ;

ISENBERG, G ;

FOGARTY, KE ;

FREDRIC, FS .

SCIENCE, 1995, 268 (5216) :1483-1487

← 1 2 3 4 5 6 7 →