Catalytic Asymmetric Bromoamination of Chalcones: Highly Efficient Synthesis of Chiral α-Bromo-β-Amino Ketone Derivatives

被引：159

作者：

Cai, Yunfei ^{[1
]}

Liu, Xiaohua ^{[1
]}

Hui, Yonghai ^{[1
]}

Jiang, Jun ^{[1
]}

Wang, Wentao ^{[1
]}

Chen, Weiliang ^{[1
]}

Lin, Lili ^{[1
]}

Feng, Xiaoming ^{[1
]}

机构：

[1] Sichuan Univ, Minist Educ, Coll Chem, Key Lab Green Chem & Technol, Chengdu 610064, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 35期

基金：

中国国家自然科学基金;

关键词：

asymmetric catalysis; bromoamination; chalcones; scandium; sulfonamides; FRIEDEL-CRAFTS ALKYLATION; STEREOSELECTIVE AMINOBROMINATION; CONJUGATED DIENES; OLEFINS; DIAMINATION; ALDEHYDES; NITROGEN; INDOLES; TSNH2; SCOPE;

D O I：

10.1002/anie.201002355

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Stand and deliver: The first highly regio- and enantioselective bromoamination of chalcones has been developed which proceeds via an unusual bromonium-based mechanism to deliver the title compounds. Excellent results were obtained using 0.05 mol % of the C2-symmetric N,N'-dioxide/scandium(III) complex under mild conditions (see scheme). © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：6160 / 6164

页数：5

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