Selectivity of inhibition of matrix metalloproteases MMP-3 and MMP-2 by succinyl hydroxamates and their carboxylic acid analogues is dependent on p3′ group chirality

被引：25

作者：

Fray, MJ ^{[1
]}

Burslem, MF

Dickinson, RP

机构：

[1] Pfizer Global Res & Dev, Dept Discovery Chem, Sandwich CT13 9NJ, Kent, England

[2] Pfizer Global Res & Dev, Dept Discovery Biol, Sandwich CT13 9NJ, Kent, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(00)00719-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Structure-activity relationships are described for a series of succinyl hydroxamic acids 1a-o and their carboxylic acid analogues 2a-o as inhibitors of matrix metalloproteases MMP-3 and MMP-2. For this series (P1' =(CH2)(3)Ph, P2'=t-Bu) selectivity for the inhibition of MMP-2 was found to be strongly dependent on P3' (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：567 / 570

页数：4

共 37 条

[1] GELATINASE ACTIVITY DURING WOUND-HEALING [J].

AGREN, MS .

BRITISH JOURNAL OF DERMATOLOGY, 1994, 131 (05) :634-640

[2] Collagenase 2 (MMP-8) expression in murine tissue-remodeling processes -: Analysis of its potential role in postpartum involution of the uterus [J].

Balbín, M ;

Fueyo, A ;

Knäuper, V ;

Pendás, AM ;

López, JM ;

Jiménez, MG ;

Murphy, G ;

López-Otín, C .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (37) :23959-23968

[3] STROMELYSIN-1 - 3-DIMENSIONAL STRUCTURE OF THE INHIBITED CATALYTIC DOMAIN AND OF THE C-TRUNCATED PROENZYME [J].

BECKER, JW ;

MARCY, AI ;

ROKOSZ, LL ;

AXEL, MG ;

BURBAUM, JJ ;

FITZGERALD, PMD ;

CAMERON, PM ;

ESSER, CK ;

HAGMANN, WK ;

HERMES, JD ;

SPRINGER, JP .

PROTEIN SCIENCE, 1995, 4 (10) :1966-1976

[4]

Beckett R. P., 1995, PCT. Int. Appl., Patent No. [WO 9519956 A1, 9519956]

[5]

Beckett RP, 1996, EXPERT OPIN THER PAT, V6, P1305

[6] Recent advances in matrix metalloproteinase inhibitor research [J].

Beckett, RP ;

Davidson, AH ;

Drummond, AH ;

Huxley, P ;

Whittaker, M .

DRUG DISCOVERY TODAY, 1996, 1 (01) :16-26

[7] Matrix metalloproteinase inhibitors 1998 [J].

Beckett, RP ;

Whittaker, M .

EXPERT OPINION ON THERAPEUTIC PATENTS, 1998, 8 (03) :259-282

[8]

BECKETT RP, 1996, Patent No. 9633165

[9]

BEELEY NRA, 1995, Patent No. 9504033

[10]

BENDER S, 1997, 2 WINT C MED BIOORG

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