Exploratory and habituation phenotype of heterozygous and homozygous COMT knockout mice

被引：33

作者：

Babovic, Daniela

O'Tuathaigh, Colm M.

O'Sullivan, Gerard J.

Clifford, Jeremiah J.

Tighe, Orna

Croke, David T.

Karayiorgou, Maria

Gogos, Joseph A.

Cotter, David

Waddington, John L.

机构：

[1] Royal Coll Surgeons Ireland, Dublin 2, Ireland

[2] Columbia Univ, New York, NY USA

[3] Royal Coll Surgeons Ireland, Dept Psychiat, Dublin 2, Ireland

来源：

BEHAVIOURAL BRAIN RESEARCH | 2007年 / 183卷 / 02期

基金：

爱尔兰科学基金会;

关键词：

COMT; knockout mice; behavioural phenotype; ethogram; exploration; habituation; schizophrenia;

D O I：

10.1016/j.bbr.2007.07.006

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Catechol-O-methyltransferase (COMT) inactivates dopamine in prefrontal cortex and is associated clinically with a schizophrenia endophenotype. Using an ethologically based approach, the phenotype of mice with heterozygous COMT deletion was characterised by decreased rearing with increased sifting and chewing. Heterozygous COMT deletion is associated with a distinctive phenotype. This differs from that which we have reported previously for heterozygous deletion of the schizophrenia risk gene neuregulin-1. (C) 2007 Elsevier B.V. All rights reserved.

引用

收藏

页码：236 / 239

页数：4

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