Rarity of AKT1 and AKT3 E17K mutations in squamous cell carcinoma of lung

被引:20
作者
Do, Hongdo [1 ,2 ]
Salemi, Renato [2 ]
Murone, Carmel [3 ,4 ]
Mitchell, Paul L. [3 ,4 ]
Dobrovic, Alexander [1 ,2 ]
机构
[1] Peter MacCallum Canc Ctr, Dept Pathol, Mol Pathol Res & Dev Lab, Melbourne, Vic, Australia
[2] Univ Melbourne, Dept Pathol, Parkville, Vic 3052, Australia
[3] Austin Hosp, Dept Med Oncol, Heidelberg, Vic 3084, Australia
[4] Austin Hosp, Ludwig Inst Med Res, Heidelberg, Vic 3084, Australia
关键词
AKT; E17K; somatic mutation; squamous cell carcinoma; lung cancer; high resolution melting; CANCER;
D O I
10.4161/cc.9.21.13654
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
引用
收藏
页码:4411 / 4412
页数:2
相关论文
共 8 条
[1]   Perturbations of the AKT signaling pathway in human cancer [J].
Altomare, DA ;
Testa, JR .
ONCOGENE, 2005, 24 (50) :7455-7464
[2]  
BLEEKER FE, 2008, ONCOGENE
[3]   A transforming mutation in the pleckstrin homology domain of AKT1 in cancer [J].
Carpten, John D. ;
Faber, Andrew L. ;
Horn, Candice ;
Donoho, Gregory P. ;
Briggs, Stephen L. ;
Robbins, Christiane M. ;
Hostetter, Galen ;
Boguslawski, Sophie ;
Moses, Tracy Y. ;
Savage, Stephanie ;
Uhlik, Mark ;
Lin, Aimin ;
Du, Jian ;
Qian, Yue-Wei ;
Zeckner, Douglas J. ;
Tucker-Kellogg, Greg ;
Touchman, Jeffrey ;
Patel, Ketan ;
Mousses, Spyro ;
Bittner, Michael ;
Schevitz, Richard ;
Lai, Mei-Huei T. ;
Blanchard, Kerry L. ;
Thomas, James E. .
NATURE, 2007, 448 (7152) :439-U1
[4]   A novel AKT3 mutation in melanoma tumours and cell lines [J].
Davies, M. A. ;
Stemke-Hale, K. ;
Tellez, C. ;
Calderone, T. L. ;
Deng, W. ;
Prieto, V. G. ;
Lazar, A. J. F. ;
Gershenwald, J. E. ;
Mills, G. B. .
BRITISH JOURNAL OF CANCER, 2008, 99 (08) :1265-1268
[5]   Detection of the transforming AKT1 mutation E17K in non-small cell lung cancer by high resolution melting [J].
Do H. ;
Solomon B. ;
Mitchell P.L. ;
Fox S.B. ;
Dobrovic A. .
BMC Research Notes, 1 (1)
[6]   RETRACTED: A Small Molecule Inhibits Akt through Direct Binding to Akt and Preventing Akt Membrane Translocation (Retracted Article) [J].
Kim, Donghwa ;
Sun, Mei ;
He, Lili ;
Zhou, Qing-Hua ;
Chen, Jun ;
Sun, Xia-Meng ;
Bepler, Gerold ;
Sebti, Said M. ;
Cheng, Jin Q. .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (11) :8383-8394
[7]   Mutational analysis of oncogenic AKT E17K mutation in common solid cancers and acute leukaemias [J].
Kim, M. S. ;
Jeong, E. G. ;
Yoo, N. J. ;
Lee, S. H. .
BRITISH JOURNAL OF CANCER, 2008, 98 (09) :1533-1535
[8]  
MALANGA D, 2007, CELL CYCLE, V7