Synergistic activities of fluconazole and voriconazole with terbinafine against four Candida species determined by checkerboard, time-kill, and Etest methods

被引:48
作者
Cantón, E
Pemán, J
Gobernado, M
Viudes, A
Espinel-Ingroff, A
机构
[1] Hosp Univ Fe, Unidad Microbiol Expt, Ctr Invest, Valencia 46009, Spain
[2] Hosp Univ Fe, Microbiol Serv, Valencia 46009, Spain
[3] VCU, Med Ctr, Div Infect Dis, Richmond, VA USA
关键词
D O I
10.1128/AAC.49.4.1593-1596.2005
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The in vitro activities of fluconazole or voriconazole plus terbinafine were evaluated against 20 Candida isolates by the checkerboard, time-kill, and Etest methods. Synergism (C. albicans, C glabrata, and C. tropicalis) and indifference (C. krusei) were observed. Correlation among methods was good. The Etest is a suitable method to determine drug interactions.
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页码:1593 / 1596
页数:4
相关论文
共 19 条
[1]   In vitro activities of pentamidine, pyrimethamine, trimethoprim, and sulfonamides against Aspergillus species [J].
Afeltra, J ;
Meis, JFGM ;
Vitale, RG ;
Mouton, JW ;
Verweij, PE .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (06) :2029-2031
[2]   In vivo pharmacokinetics and pharmacodynamics of a new triazole, voriconazole, in a murine candidiasis model [J].
Andes, D ;
Marchillo, K ;
Stamstad, T ;
Conklin, R .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2003, 47 (10) :3165-3169
[3]   TERBINAFINE - A REVIEW OF ITS PHARMACODYNAMIC AND PHARMACOKINETIC PROPERTIES, AND THERAPEUTIC POTENTIAL IN SUPERFICIAL MYCOSES [J].
BALFOUR, JA ;
FAULDS, D .
DRUGS, 1992, 43 (02) :259-284
[4]   In-vitro interaction of terbinafine with amphotericin B, fluconazole and itraconazole against clinical isolates of Candida albicans [J].
Barchiesi, F ;
Di Francesco, LF ;
Compagnucci, P ;
Arzeni, D ;
Giacometti, A ;
Scalise, G .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1998, 41 (01) :59-65
[5]   In vitro activities of terbinafine in combination with fluconazole and itraconazole against isolates of Candida albicans with reduced susceptibility to azoles [J].
Barchiesi, F ;
DiFrancesco, LF ;
Scalise, G .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (08) :1812-1814
[6]   Quality control limits for broth microdilution susceptibility tests of ten antifungal agents [J].
Barry, AL ;
Pfaller, MA ;
Brown, SD ;
Espinel-Ingroff, A ;
Ghannoum, MA ;
Knapp, C ;
Rennie, RP ;
Rex, JH ;
Rinaldi, MG .
JOURNAL OF CLINICAL MICROBIOLOGY, 2000, 38 (09) :3457-3459
[7]  
Canton E, 2004, Rev Esp Quimioter, V17, P48
[8]   Patterns of amphotericin B killing kinetics against seven Candida species [J].
Cantón, E ;
Pemán, J ;
Gobernado, M ;
Viudes, A ;
Espinel-Ingroff, A .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2004, 48 (07) :2477-2482
[9]   FLUCONAZOLE - A REVIEW OF ITS PHARMACODYNAMIC AND PHARMACOKINETIC PROPERTIES, AND THERAPEUTIC POTENTIAL IN SUPERFICIAL AND SYSTEMIC MYCOSES [J].
GRANT, SM ;
CLISSOLD, SP .
DRUGS, 1990, 39 (06) :877-916
[10]  
Hoffman HL, 2002, EXPERT OPIN INV DRUG, V11, P409