The role of neuronal nicotinic acetylcholine receptors in antinociception: Effects of ABT-594

被引：33

作者：

Decker, MW ^{[1
]}

Curzon, P ^{[1
]}

Holladay, MW ^{[1
]}

Nikkel, AL ^{[1
]}

Bitner, RS ^{[1
]}

Bannon, AW ^{[1
]}

Donnelly-Roberts, DL ^{[1
]}

Puttfarcken, PS ^{[1
]}

Kuntzweiler, TA ^{[1
]}

Briggs, CA ^{[1
]}

Williams, M ^{[1
]}

Arneric, SP ^{[1
]}

机构：

[1] Abbott Labs, Div Pharmaceut Prod, Neurol & Urol Dis Res, Dept 47W, Abbott Pk, IL 60064 USA

来源：

JOURNAL OF PHYSIOLOGY-PARIS | 1998年 / 92卷 / 3-4期

关键词：

ABT-594; nucleus raphe magnus; nicotinic acetylcholine receptor; serotonin; antinociception;

D O I：

10.1016/S0928-4257(98)80014-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

ABT-594, a nicotinic acetylcholine receptor agonist, has antinociceptive effects in rat models of acute thermal, persistent chemical, and neuropathic pain. Direct injection of ABT-594 into the nucleus raphe magnus (NRM) is antinociceptive in a thermal threshold test and destruction of serotonergic neurons in the NRM attenuates the effect of systemic ABT-594. However, lidocaine-inactivation of the NRM prevents the antinociceptive effect of systemic (-)-nicotine bur not that of systemic ABT-594. ((C)Elsevier, Paris).

引用

页码：221 / 224

页数：4

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