Fabrication of chemical microarrays by efficient immobilization of hydrazide-linked substances on epoxide-coated glass surfaces

(Chemical Equation Presented) Fixed to the spot: A new, efficient, and simple immobilization technique for the construction of chemical microarrays has been developed. This technique is applicable to the site-selective attachment of diverse substances, including small molecules, carbohydrates, and peptides, to glass slides (see picture). The chemical microarrays fabricated by using this method were applied to screening peptide and small-molecule binding to proteins. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.