Presynaptic and Ca2+-independent PKC subspecies modulates NMDAR1 current

被引：11

作者：

Koga, T

Sakai, N

Tanaka, C

Saito, N

机构：

[1] KOBE UNIV,BIOSIGNAL RES CTR,MOLEC PHARMACOL LAB,NADA KU,KOBE 657,JAPAN

[2] KOBE UNIV,SCH MED,DEPT PHARMACOL,KOBE 650,JAPAN

来源：

NEUROREPORT | 1996年 / 7卷 / 02期

关键词：

NMDA receptor; protein kinase C; subspecies; calcium; metabotropic glutamate receptor; Xenopus oocyte;

D O I：

10.1097/00001756-199601310-00024

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

WE have studied the properties of the protein kinase C (PKC) subspecies that modulates the NMDA receptor (NMDAR1). The current through homomeric NMDAR1 expressed in Xenopus oocytes was increased by 200-500% by phorbol ester and also by activation of a metabotropic glutamate receptor (mGluR1) expressed in the same oocytes. This potentiation of the NMDAR1 current was not inhibited by the intracellular injection of EGTA. Intracellular injection of epsilon-PKC, a presynaptic PKC subspecies, potentiated the NMDAR1 current more efficiently than did the Ca2+-dependent gamma-PKC, a postsynaptic subspecies of the enzyme. Our findings suggested that the presynaptic NMDA receptor could be potentiated in a Ca2+-independent manner by the activation of presynaptic PKC subspecies.

引用

页码：477 / 480

页数：4

共 25 条

[1] QUISQUALATE METABOTROPIC RECEPTORS MODULATE NMDA CURRENTS AND FACILITATE INDUCTION OF LONG-TERM POTENTIATION THROUGH PROTEIN-KINASE-C [J].