Real-time, contrast enhanced photoacoustic imaging of cancer in a mouse window chamber

被引：38

作者：

Olafsson, Ragnar ^{[1
]}

Bauer, Daniel R. ^{[1
]}

Montilla, Leonardo G. ^{[1
]}

Witte, Russell S. ^{[1
]}

机构：

[1] Univ Arizona, Dept Radiol, Tucson, AZ 85724 USA

来源：

OPTICS EXPRESS | 2010年 / 18卷 / 18期

基金：

美国国家科学基金会;

关键词：

TUMORS;

D O I：

10.1364/OE.18.018625

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

A clinical ultrasound scanner and 14 MHz linear array collected real-time photoacoustic images (PAI) during an injection of gold nanorods (GNRs) near the region of a mature PC-3 prostate tumor in mice implanted with a skin flap window chamber. Three dimensional spectroscopic PAI (690-900nm) was also performed to investigate absorption changes near the tumor and enhance specific detection of GNRs. Whereas GNRs improved PAI contrast (+ 18 dB), the photoacoustic spectrum was consistent with the elevated near infrared absorption of GNRs. The versatile imaging platform potentially accelerates development of photoacoustic contrast agents and drug delivery for cancer imaging and therapy. (C) 2010 Optical Society of America

引用

页码：18625 / 18632

页数：8

共 18 条

[1] Electromigration and critical product in eutectic SnPb solder lines at 100 °C [J].