Treatment of McLeod phenotype chronic granulomatous disease with reduced-intensity conditioning and unrelated-donor umbilical cord blood transplantation

被引：25

作者：

Suzuki, Nobuhiro

Hatakeyama, Naoki

Yamamoto, Masaki

Mizue, Nobuo

Kuroiwa, Yuki

Yoda, Minami

Takahashi, Junko

Tani, Yoshihiko

Tsutsumi, Hiroyuki

机构：

[1] Sapporo Med Univ, Sch Med, Dept Pediat, Chuo Ku, Sapporo, Hokkaido 0608543, Japan

[2] Hakodate City Gen Hosp, Dept Pediat, Hakodate, Hokkaido, Japan

[3] Japanese Red Cross Osaka Blood Ctr, Res Sect 1, Osaka, Japan

来源：

INTERNATIONAL JOURNAL OF HEMATOLOGY | 2007年 / 85卷 / 01期

关键词：

chronic granulomatous disease; McLeod phenotype; reduced-intensity conditioning; umbilical cord blood; transplantation; aspergillosis;

D O I：

10.1532/IJH9706129

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Patients with chronic granulomatous disease (CGD) complicated by antimycotics-refractory invasive aspergillosis have an extremely poor prognosis if they cannot undergo allogeneic hematopoietic stem cell transplantation from a suitable related donor while in good clinical condition. We successfully treated a 20-year-old man with very rare McLeod phenotype CGD with reduced-intensity conditioning and unrelated-donor umbilical cord blood transplantation. We postulate that reduced-intensity conditioning-allogeneic hematopoietic stem cell transplantation is a promising therapeutic strategy for patients with CGD even if only unrelated-donor umbilical cord blood is available.

引用

页码：70 / 72

页数：3

共 6 条

[1] Rapid and complete donor chimerism in adult recipients of unrelated donor umbilical cord blood transplantation after reduced-intensity conditioning [J].

Barker, JN ;

Weisdorf, DJ ;

DeFor, TE ;

Blazar, BR ;

Miller, JS ;

Wagner, JE .

BLOOD, 2003, 102 (05) :1915-1919

[2] Successful umbilical cord blood stem cell transplantation for chronic granulomatous disease [J].

Bhattacharya, A ;

Slatter, M ;

Curtis, A ;

Chapman, CE ;

Barge, D ;

Jackson, A ;

Flood, TJ ;

Abinun, M ;

Cant, AJ ;

Gennery, AR .

BONE MARROW TRANSPLANTATION, 2003, 31 (05) :403-405

[3] Successful treatment of invasive aspergillosis in chronic granulomatous disease by granulocyte transfusions followed by peripheral blood stem cell transplantation [J].

Bielorai, B ;

Toren, A ;

Wolach, B ;

Mandel, M ;

Golan, H ;

Neumann, Y ;

Kaplinisky, C ;

Weintraub, M ;

Keller, N ;

Amariglio, N ;

Paswell, J ;

Rechavi, G .

BONE MARROW TRANSPLANTATION, 2000, 26 (09) :1025-1028

[4] Treatment of chronic granulomatous disease with nonmyeloablative conditioning and a T-cell-depleted hematopoietic allograft. [J].

Horwitz, ME ;

Barrett, AJ ;

Brown, MR ;

Carter, CS ;

Childs, R ;

Gallin, JI ;

Gress, RE ;

Holland, SM ;

Linton, GF ;

Miller, JA ;

Leitman, SF ;

Read, EJ ;

Schermerhorn, J ;

Malech, HL .

NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (12) :881-888

[5] Treatment of chronic granulomatous disease with myeloablative conditioning and an unmodified hemopoietic allograft:: a survey of the European experience, 1985-2000 [J].

Seger, RA ;

Gungor, T ;

Belohradsky, BH ;

Blanche, S ;

Bordigoni, P ;

Di Bartolomeo, P ;

Flood, T ;

Landais, P ;

Müller, S ;

Ozsahin, H ;

Passwell, JH ;

Porta, F ;

Slavin, S ;

Wulffraat, N ;

Zintl, F ;

Nagler, A ;

Cant, A ;

Fischer, A .

BLOOD, 2002, 100 (13) :4344-4350

[6]

YODA M, 2006, J JPN PEDIAT SOC, V110, P38

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